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| '''Autoimmune disease''' is defined as ''a disease state characterised by a specific antibody or cell mediated response against the body's own tissues ('self' antigens). | | '''Autoimmune disease''' is defined as ''a disease state characterised by a specific antibody or cell mediated response against the body's own tissues ('self' antigens). |
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− | The breakdown of [[Immune Tolerance - WikiBlood|tolerance]] to self antigens and the failure to regulate pathological immune responses are both responsible for autoimmune diseases. It has been shown in mice that thymectomy causes autoimmune disease, and plays a very important role in the recognition of 'self'. | + | The breakdown of [[Immune Tolerance|tolerance]] to self antigens and the failure to regulate pathological immune responses are both responsible for autoimmune diseases. It has been shown in mice that thymectomy causes autoimmune disease, and plays a very important role in the recognition of 'self'. |
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| Particular individuals may be more susceptible to autoimmune diseases due to: | | Particular individuals may be more susceptible to autoimmune diseases due to: |
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| !width="200"|Cell mediated | | !width="200"|Cell mediated |
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− | | '''Type of hypersensitivity''' || [[Type II Hypersensitivity - WikiBlood|Type II]] || [[Type III Hypersensitivity - WikiBlood|Type III]] || [[Type IV Hypersensitivity - WikiBlood|Type IV]] | + | | '''Type of hypersensitivity''' || [[Type II Hypersensitivity|Type II]] || [[Type III Hypersensitivity|Type III]] || [[Type IV Hypersensitivity|Type IV]] |
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| | '''Pathogenesis''' || Antibody to cell surface or matrix antigens || Antibody to soluble self antigens || T cell and macrophage activation to self antigens | | | '''Pathogenesis''' || Antibody to cell surface or matrix antigens || Antibody to soluble self antigens || T cell and macrophage activation to self antigens |
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− | | '''Examples of diseases''' || [[Immune Mediated Haemolytic Anaemia|Immune mediated haemolytic anaemia (IMHA) || [[Systemic Lupus Erythematosus]] (SLE) || Rheumatoid arthritis | + | | '''Examples of diseases''' || [[Immune Mediated Haemolytic Anaemia|Immune mediated haemolytic anaemia (IMHA) || [[Systemic Lupus Erythematosus]] (SLE) || [[Rheumatoid Arthritis]] |
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| | || [[Immune Mediated Thrombocytopaenia|Immune mediated thrombocytopaenia (IMTP)]]|| || [[Diabetes Mellitus]] type 1 | | | || [[Immune Mediated Thrombocytopaenia|Immune mediated thrombocytopaenia (IMTP)]]|| || [[Diabetes Mellitus]] type 1 |
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− | | || [[Myasthenia Gravis|Myasthenia gravis]] || || Hypothyroidism (lymphocytic throiditis) | + | | || [[Myasthenia Gravis|Myasthenia gravis]] || || [[Hypothyroidism]] (lymphocytic throiditis) |
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− | | || [[Pemphigus Vulgaris]] || || Hypoadrenocorticism (Addisons disease) | + | | || [[Pemphigus]] || || [[Hypoadrenocorticism]] (Addisons disease) |
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− | | || [[Bullous pemphigoid]] || || | + | | || [[Bullous Pemphigoid]] || || |
| |} | | |} |
− | | + | <br><br> |
| + | {{Jim Bee 2007}} |
| [[Category:Autoimmune Diseases]] | | [[Category:Autoimmune Diseases]] |