Difference between revisions of "Actinobacillus suis"
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==Introduction== | ==Introduction== | ||
| − | ''A.suis'' is a beta-haemolytic '''Gram-negative bacterium'''. | + | ''A.suis'' is a beta-haemolytic '''Gram-negative bacterium'''. It has many strains due to differences in their '''lipopolysaccharides (LPS)''', which are known as ''''O' antigens''' and are referred to as '''O1,O2''' and '''O3''' and '''capsules (CPS)''', refered to as''''K' antigen''' with variants described as '''K1, K2''' and '''K3'''. More than 95% of A. suis clinical isolates are cross-reactive with O1/K1 or O2/K3 antiserum and more severe infection were noted with O2/K2 srain <ref name="Slavic et al., 2000">Slavic, D., DeLay, J., Hayes, M.A., MacInnes, J.I.(2000) '''Comparative pathogenicity of different Actinobacillus suis O/K serotypes'''. ''Canadian Journal of Veterinary Research'', 64(2):81-87.</ref>. This '''opportunistic''' bacteria mainly causes [[Actinobacillosis - Pig| '''actinobacillosis in pigs''']], but has also been linked to diseases in neonatal calfs, waterfowl, alpacas, horses and [[Actinobacillus suis#signalment| various other species]]. |
Other haemolytic strains of ''Actinobacillus species'' have been linked to various diseases in horses such as [[Actinobacillus equuli| ''Actinobacillus equuli'']] and [[Actinobacillosis - Cattle|''Actinobacillus ligneresii'']]. The latter species also causes [[Actinobacillosis - Cattle|wooden tongue in cattle]]. | Other haemolytic strains of ''Actinobacillus species'' have been linked to various diseases in horses such as [[Actinobacillus equuli| ''Actinobacillus equuli'']] and [[Actinobacillosis - Cattle|''Actinobacillus ligneresii'']]. The latter species also causes [[Actinobacillosis - Cattle|wooden tongue in cattle]]. | ||
| − | ''A.suis'' have genes that encode toxins similar to apxI and apxII of [[Actinobacillus pleuropneumoniae| ''A. pleuropneumoniae'']], but they are less virulent. Once an animal is infected with ''A.suis'' it can provide '''partial cross protection against ''A. pleuropneumoniae''''' | + | ''A.suis'' are able to resist bile and serum and have genes that encode toxins similar to apxI and apxII of [[Actinobacillus pleuropneumoniae| ''A. pleuropneumoniae'']], but they are less virulent. Once an animal is infected with ''A.suis'' it can provide '''partial cross protection against ''A. pleuropneumoniae'''''. |
==Signalment== | ==Signalment== | ||
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==Epidemiology== | ==Epidemiology== | ||
| − | The epidemiology of ''A.Suis'' is poorly understood | + | The epidemiology of ''A.Suis'' is poorly understood, although it can be found in the tonsils and upper respiratory tract of both healthy and diseased pigs, and isolates are genetically and biochemically similar. It is believed to be spread via '''aerososl infection''' and '''invasion of the upper respiratory tract'''. It is thought to colonise piglets in the first three weeks of life but not all piglets become clinically affected and some can become carriers. |
==Diagnosis== | ==Diagnosis== | ||
| − | ''A.Suis'' is difficult to culture and most of the O1 strains analyzed possess '''pustulan''' (1-6,beta-D-glucan)which is a major component of fungal and lichen cell walls. Therefore, many animals have antibodies to this polysaccharide in the absence of exposure to A. suis. These antibodies may provide naive pigs with some level of protection against the O1 strains <ref name="MacInnes and Desrosiers, 1999">MacInnes, J.I., Desrosiers, R.(1999)''' Agents of the "suis-ide diseases" of swine: Actinobacillus suis, Haemophilus parasuis, and Streptococcus suis'''. ''Canadian Journal of Veterinary Research'', 63(2):83-89; 52 ref.</ref>, <ref name="Slavic et al., 2000"/>. For more information see [[Actinobacillosis - Pig| '''actinobacillosis in pigs''']]. | + | ''A.Suis'' is difficult to culture and most of the O1 strains analyzed possess '''pustulan''' (1-6,beta-D-glucan)which is a major component of fungal and lichen cell walls. Therefore, many animals have antibodies to this polysaccharide in the absence of exposure to ''A. suis''. These antibodies may provide naive pigs with some level of protection against the O1 strains <ref name="MacInnes and Desrosiers, 1999">MacInnes, J.I., Desrosiers, R.(1999)''' Agents of the "suis-ide diseases" of swine: Actinobacillus suis, Haemophilus parasuis, and Streptococcus suis'''. ''Canadian Journal of Veterinary Research'', 63(2):83-89; 52 ref.</ref>, <ref name="Slavic et al., 2000"/>. For more information see [[Actinobacillosis - Pig| '''actinobacillosis in pigs''']]. |
==Distribution== | ==Distribution== | ||
Revision as of 11:26, 23 June 2011
Also known as: A.suis
| Scientific Classification | |
|---|---|
| Kingdom | Bacteria |
| Phylum | Proteobacteria |
| Class | Zymobacteria |
| Sub-class | Alphaproteobacteria |
| Order | Pasteurellales |
| Family | Pasteurellaceae |
| Genus | Actinobacillus |
| Species | Actinobacillus suis |
Introduction
A.suis is a beta-haemolytic Gram-negative bacterium. It has many strains due to differences in their lipopolysaccharides (LPS), which are known as 'O' antigens and are referred to as O1,O2 and O3 and capsules (CPS), refered to as'K' antigen with variants described as K1, K2 and K3. More than 95% of A. suis clinical isolates are cross-reactive with O1/K1 or O2/K3 antiserum and more severe infection were noted with O2/K2 srain [1]. This opportunistic bacteria mainly causes actinobacillosis in pigs, but has also been linked to diseases in neonatal calfs, waterfowl, alpacas, horses and various other species.
Other haemolytic strains of Actinobacillus species have been linked to various diseases in horses such as Actinobacillus equuli and Actinobacillus ligneresii. The latter species also causes wooden tongue in cattle.
A.suis are able to resist bile and serum and have genes that encode toxins similar to apxI and apxII of A. pleuropneumoniae, but they are less virulent. Once an animal is infected with A.suis it can provide partial cross protection against A. pleuropneumoniae.
Signalment
A.suis can infect all ages of pigs and it is thought that incidence of the disease is increasing, especially in North American high-health-status herds.
Wild hosts include anatidae (ducks, geese and swans) and Coypu but A.suis can also affect domestic species including cattle, sheep, goats, alpacas, zebu, dogs, cats and tentive links to equine disease have been recorded (although this is thought to be be an A.suis-like microorganism rather than A.suis itself). A.suis is not considered to be a zoonosis,but there is a report of a human infection after a pig bite [2].
Clinical signs
For clinical signs in pigs see actinobacillosis in pigs. In other species, A.suis causes pneumonia like symptoms and localised infections in neonatal calf, airsaculitis in waterfowl, and polyarthritis in alpacas and, to septicaemia, acute haemorrhagic pulmonary infarction and necrotizing pneumonia in horses.
Epidemiology
The epidemiology of A.Suis is poorly understood, although it can be found in the tonsils and upper respiratory tract of both healthy and diseased pigs, and isolates are genetically and biochemically similar. It is believed to be spread via aerososl infection and invasion of the upper respiratory tract. It is thought to colonise piglets in the first three weeks of life but not all piglets become clinically affected and some can become carriers.
Diagnosis
A.Suis is difficult to culture and most of the O1 strains analyzed possess pustulan (1-6,beta-D-glucan)which is a major component of fungal and lichen cell walls. Therefore, many animals have antibodies to this polysaccharide in the absence of exposure to A. suis. These antibodies may provide naive pigs with some level of protection against the O1 strains [3], [1]. For more information see actinobacillosis in pigs.
Distribution
Worldwide
References
- ↑ 1.0 1.1 Slavic, D., DeLay, J., Hayes, M.A., MacInnes, J.I.(2000) Comparative pathogenicity of different Actinobacillus suis O/K serotypes. Canadian Journal of Veterinary Research, 64(2):81-87.
- ↑ Escande, F., Bailly, A., Bone, S., Lemozy, J. (1996)Actinobacillus suis infection after a pig bite. Lancet (British edition), 348(9031):888; 5 ref
- ↑ MacInnes, J.I., Desrosiers, R.(1999) Agents of the "suis-ide diseases" of swine: Actinobacillus suis, Haemophilus parasuis, and Streptococcus suis. Canadian Journal of Veterinary Research, 63(2):83-89; 52 ref.
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