Avian Encephalomyelitis

Also known as: AE— Epidemic tremor in chickens

Introduction

Avian Encephalomyelitis (AE) is commonly known as epidemic tremor in chickens and is caused by a hepatovirus avian encephalomyelitis-like virus 1 (AEV). The disease is of economic concern to breeders and layers as it causes a decrease in egg production in laying hens, a decrease in egg hatchability, neurological diseases in chicks under three weeks of age and affected chicks that that survive are considered unlikely to be profitable.

The disease is spread horizontally, via the faecal-oral route and chicks from non-immune layers under the age of three weeks are neurologically affected. Vertical transmission can also occur from infected layers to their chicks. The virus may be shed for several weeks. Once a bird becomes infected with the disease or is vaccinated it is immune to AE for life, some birds are left blind. AE is not considered a zoonosis.

Signalment

The domestic host for AEV is the chicken but it can also infect species of partridge, turkey, quail, guineafowl and pheasants. The infection causes the most serious disease in chicks under 3 weeks of age and older chicks show fewer clinical signs. Laying hens show a temporary reduction in their productivity . The incubation period varies from 5 to 14 days depending on the route of infection.

Clinical Signs

The disease causes a range of neurological signs in chicks under 3 weeks, ranging from ataxia, rapid tremor of the head and neck, drooping of the wings, weakness, paralysis, exercise intolerance to blindness and changes in vocalisation. It also causes weight loss, lameness, and unthriftiness. Affected chicks sit on their hocks, and cannot move well and many fall over onto their sides. Mortality can be as high as 25% with higher morbity rates of up to 60%. Older chicks show fewer neurological signs and in laying hens the disease causes a temporary reduction (2 weeks) in egg production and a decrease in droppings.

Diagnosis

The following methods have been used to help diagnose Avian Encephalomyelitis; Virus Neutralization test, Agar Gel test, Embryo Susceptibility test and more recently an Elisa test. All of the tests show the presence of antibodies and indicate exposure to the disease and not necessarily a current infection. Diagnosis can be confirmed by either histopathology or by virus isolation. Classic diagnosis is typically made by the presence of brain lesions shown histologically.

Grossly, lymphocytic infiltration of the muscular region of the ventriculus has also been noted as well as perivascular infiltration within the brain and chord, with the exception of the cerebellum, where lesions can be found only in the nucleus cerebellaris. Pathognomonic lesions can be found within the midbrain and rotundua and ovidalis nucleus (microglisosis) and proventriculus (dense nodules within the muscular wall). Lesions can also be present in the pancreas.

Differential diagnosis: include Newcastle disease (ND), Equine encephalomyelitis infection, nutritional disturbances ( rickets, encephalomalacia, riboflavin deficiency), and Marek’s disease

Distribution

Worldwide, the disease has been documented in Africa, Asia, Australia, Europe, and North and South America.

Treatment

There is no treatment for chicks infected with avian encephalomyelitis (AE). . Surviving chicks will be immune to AE for life.

Control

In regions where AE is prevalent an effective way of preventing AE is to vaccinate pullets several weeks before they come into lay. Vaccination protects the flock from a reduction in egg production and prevents vertical transmission of the virus to chicks by providing the chicks with a sufficient level of maternal derived antibodiesas because there is only one serotype for the AEV. There are live and attenuated vaccinations available which can be administered in drinking water or as an eye drop, the latter being more effective. vaccination by eye-drop of only 10% of a flock gave the same results as drinking water application

References

Avian Encephalomyelitis Learning Resources
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