Calve Legg-Perthe's Disease

• Almost exlusively in small dogs, particularly terriers and poodles
• Clinical signs appear at age of 4-11 months
• Grossly:
  • Aseptic ischaemic necrosis in central parts of femoral head
    • Possibly due to occlusion of blood vessels
  • Fragmentation of trabecular bone
  • Collapse of femoral head
  • Revascularisation of femoral head
  • Formation of new bone and osteophyte formation around femoral head and acetabular rim prior to old bone reabsorption
  • -> severe degenerative arthropathy