Campylobacter jejuni
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Campylobacter jejuni
- Widespread on farms - hyperendemic
- Carried as commensals in intestines of cattle, sheep, dogs, wild birds and especially chickens
- Farm animals regularly exposed via faecal-oral route; maternal antibody protects while active immunity develops
- Animals with little exposure are very susceptible, e.g. humans, pets
- Most chicken carcasses contaminated, leading to food poisoning and enterocolitis in people from uncooked meat
- Colonisation, attachment and invasion of colonic enterocytes; toxin production
- Necrosis of colonic absorptive epithelial cells, erosion of mucosa, crypt abscesses, inflammatory infiltrate of neutrophils into mucosa causes colitis
- Enteritis and diarrhoea in susceptible dogs; treatment with enrofloxacin
- Causes abortion in ewes
- Usually asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian hepatitis occur with decreased egg production, loss of condition, haemorrhage and necrosis of liver; phase contrast microscopy demonstrates curved rods in bile; in-feed dihydrostreptomycin sulphate in outbreak
- Implicated in undifferentiated neonatal calf diarrhoea, a mixed viral enteritis in calves