Category:Asfarviridae

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Asfarviridae

Asfarviridae contains asfivirus, which is the virus of African Swine Fever. This is a serious exotic virus that should not be confused with Classical Swine Fever.


Morphology

  • Large, enveloped, icosahedral, cytoplasmic DNA virus

Virulence and Pathogenesis

  • Infects either upper respiratory tract or skin via ticks
  • Enters bloodstream in monocytes
  • Reaches viscera and bone marrow within days
  • Induces a clotting defect and hemolysis in red blood cells
  • Also affects lymphocytes:
    • Infects Th cells and causes them not to produce B-stimulating cytokines
    • Antigen-stimulated B-cells undergo apoptosis rather than producing antibody
  • General cell signal transduction is blocked, decreasing non-specific immunity

Pages in category "Asfarviridae"

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