Category:Asfarviridae
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Asfarviridae
Asfarviridae contains asfivirus, which is the virus of African Swine Fever. This is a serious exotic virus that should not be confused with Classical Swine Fever.
Morphology
- Large, enveloped, icosahedral, cytoplasmic DNA virus
Virulence and Pathogenesis
- Infects either upper respiratory tract or skin via ticks
- Enters bloodstream in monocytes
- Reaches viscera and bone marrow within days
- Induces a clotting defect and hemolysis in red blood cells
- Also affects lymphocytes:
- Infects Th cells and causes them not to produce B-stimulating cytokines
- Antigen-stimulated B-cells undergo apoptosis rather than producing antibody
- General cell signal transduction is blocked, decreasing non-specific immunity
Pages in category "Asfarviridae"
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