Category:Primary Adaptive Immunity Deficiencies

Deficiencies of Adaptive Immunity

Equine Severe Combined Immune Deficiency (Equine SCID)

• Autosomal recessive
• Occurs in 2-3% of Arabian foals
• Defect in DNA-dependent protein kinase gene
  • Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
• No functional B cells or T cells
• Foals develop infections (usually around 8 weeks of age as maternal antibody in colostrum wanes around this time)
• Foals usually die from bronchopneumonia

Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)

• Affects Basset Hounds and Corgis
• X-linked recessive defect in the gene coding for the IL-2 receptor
  • IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
• Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
• Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases

Selective IgA deficiency of German Shepherd Dogs

• Poorly understood
• Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
• [[Immunoglobulin A|IgA]] deficiency so more susceptible to mucosal disease

Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds

• Unknown aetiology
• Inherited defects
• Low levels of circulating IgM and IgG
• Impaired neutrophil function
• Causes recurrent pyrexia and infections
  • E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|IgA]]
  • E.g. Pneumocytosis in Miniature Dachshunds due to low IgG