Difference between revisions of "Category:Secondary Immunodeficiency"

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(Created page with "*There are many causes of secondary immunodeficiency **Most deficiencies are not genetic **Most are agent-induced, such as from X-ray radiation and immunosuppressive drugs ===V...")
 
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===Viral Causes===
 
===Viral Causes===
  
====Feline Leukaemia Virus (FeLV)====
+
====[[Feline Leukaemia Virus]] ====
[[Image:FeLV Electron Micrograph.jpg|thumb|right|150px|FeLV Electron Micrograph [http://phil.cdc.gov/phil/home.asp Public Health Image Library] Image #5610]]
 
[[Image:Kinetics of FeLV 2.jpg|thumb|right|150px|Kinetics of FeLV - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]
 
*Oncogenic retrovirus
 
*Causes neoplasia (lymphoma), myelosuppression (anaemia) and immunosuppression (of [[Lymphocytes#T cells|T cells]])
 
*2 strains:
 
**FeLV-A
 
***Natural strain
 
**FeLV-B
 
***Formed through FeLV-A recombining with endogenous retroviral sequences in the feline genome
 
***Increases the risks of lymphoma
 
**FeLV-C
 
***Formed from the spontaneous mutation of FeLV-A
 
***Is more myelosuppressive
 
*Virus replicates in the oropharyngeal lymphoid tissue causing a viraemia (virus circulating in the bloodstream) which then spreads to the systemic lymphoid tissue
 
*Shed in saliva
 
*Passed by oronasal route, e.g. mutual grooming
 
*Kittens between 6 weeks and 6 months are most susceptible
 
*60% of cats will become immune to the disease and recover
 
*Cats that are persistently viraemic will progress to develop FeLV-associated diseases
 
*Some cats will become viraemic again if treated with corticosteroids or stressed if the infection lies dormant in the [[Bone Marrow - Anatomy & Physiology|bone marrow]]
 
*Diagnosis:
 
**ELISA
 
**Rapid-Immuno-Migration
 
**Western Blot
 
**Virus Isolation
 
**Immunofluorescence
 
**PCR
 
*Treatment:
 
**Antibiotics for secondary infection
 
**Anti-retroviral therapy
 
*For vaccinations see [[Vaccines - WikiBlood#Cat Vaccinations|here]]
 
  
 
====Feline Immunodeficiency Virus (FIV)====
 
====Feline Immunodeficiency Virus (FIV)====
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**Anti-retroviral therapy
 
**Anti-retroviral therapy
 
*For vaccinations see [[Vaccines - WikiBlood#Cat Vaccinations|here]]
 
*For vaccinations see [[Vaccines - WikiBlood#Cat Vaccinations|here]]
 
+
[[Category:Secondary Immunodeficiency]]
 
====Bovine Immunodeficiency Virus (BIV)====
 
====Bovine Immunodeficiency Virus (BIV)====
 
*Lentivirus (non-oncogenic)
 
*Lentivirus (non-oncogenic)
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**Western Blot
 
**Western Blot
 
**PCR
 
**PCR
 
+
[[Category:Secondary Immunodeficiency]][[To Do - Blood]]
 
===Toxic Causes===
 
===Toxic Causes===
  

Revision as of 14:08, 12 August 2010

  • There are many causes of secondary immunodeficiency
    • Most deficiencies are not genetic
    • Most are agent-induced, such as from X-ray radiation and immunosuppressive drugs

Viral Causes

Feline Leukaemia Virus

Feline Immunodeficiency Virus (FIV)

  • Lentivirus
  • Subtypes A, B and D
  • Causes increased susceptibility to infections and neoplasia
  • Specifically destroys CD4+ T cells
  • Virus is present in saliva, blood and other bodily fluids
  • Feral and outdoor cats (mostly tom cats) are most at risk
  • Virus replicates in lymphoid tissue
  • Can remain asymptomatic
  • Causes pyrexia and lymphadenopathy
  • Transmitted by biting
  • Diagnosis:
    • ELISA
    • Rapid-Immuno-Migration
    • Western Blot
    • Virus Isolation
    • Immunofluorescence
    • PCR
  • Treatment:
    • Antibiotics for secondary infection
    • Anti-retroviral therapy
  • For vaccinations see here

Bovine Immunodeficiency Virus (BIV)

  • Lentivirus (non-oncogenic)
  • Causes a persistent viral infection and lymphocytosis
  • Immunocompromised cattle may develop secondary infections
  • The transmission is not well known, but the following possibilities are being researched:
    • Through milk
    • Through infected semen (e.g.artificial insemination)
    • Placental transfer
  • Diagnosis:

Toxic Causes

  • Poisons

Iatrogenic Causes

  • Drugs
    • Corticosteroids
    • Cyclosporin
    • Cytotoxic cancer therapy

Other Causes

  • Malnutrition
  • Chronic disease
  • Stress
  • Senescence

Pages in category "Secondary Immunodeficiency"

The following 3 pages are in this category, out of 3 total.