Difference between revisions of "Dermatophytosis"

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[[Image:Dermatophyte mycelium in skin.jpg|thumb|right|200px|Dermatophytosis mycelium in skin - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophyte mycelium in skin.jpg|thumb|right|200px|Dermatophytosis mycelium in skin - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophyte skin KOH.jpg|thumb|right|200px|Dermatophyte in skin using a KOH mount - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophyte skin KOH.jpg|thumb|right|200px|Dermatophyte in skin using a KOH mount - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
[[Image: Microsporum canis lesions.jpg|150px|thumb|right|''Microsporum canis'' alopecia and scaling lesions - Courtesy of Bristol BioMed Image Archive]]
 
[[Image: Ringworm dog.jpg|150px|thumb|right|Ringworm in a dog -Courtesy of Bristol BioMed Image Archive]]
 
[[Image: Trichophyton mentagrophytes dog.jpg|150px|thumb|right|Trichophyton mentagrophytes in a dog - Courtesy of Bristol BioMed Image Archive]]
 
 
[[Image:Ringworm on human arm.jpg|thumb|right|150px|Ringworm on a human arm - Wikimedia Commons]]
 
[[Image:Ringworm on human arm.jpg|thumb|right|150px|Ringworm on a human arm - Wikimedia Commons]]
 
[[Image:Dermatophytosis in a dog.jpg|thumb|right|200px|Dermatophytosis in a dog - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a dog.jpg|thumb|right|200px|Dermatophytosis in a dog - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a cow.jpg|thumb|right|200px|Dermatophytosis in a cow - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a cow.jpg|thumb|right|200px|Dermatophytosis in a cow - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a chicken.jpg|thumb|right|200px|Dermatophytosis in a chicken - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a chicken.jpg|thumb|right|200px|Dermatophytosis in a chicken - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
[[Image:Dermatophytosis dog foot.jpg|thumb|right|200px|Dermatophytosis in a dog's foot - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
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[[Image:Dermatophytosis dog foot.jpg|thumb|right|200px|Dermatophytosis lesion on a dog's leg - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a horse.jpg|thumb|right|200px|Dermatophytosis in a horse - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
 
[[Image:Dermatophytosis in a horse.jpg|thumb|right|200px|Dermatophytosis in a horse - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
  

Revision as of 16:57, 4 June 2009



Infectious agents and parasitesWikiBugs Banner.png
FUNGI



Dermatophyte arthrospores on a hair root - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophytosis mycelium in skin - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophyte in skin using a KOH mount - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Ringworm on a human arm - Wikimedia Commons
Dermatophytosis in a dog - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophytosis in a cow - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophytosis in a chicken - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophytosis lesion on a dog's leg - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath
Dermatophytosis in a horse - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath

General

  • Pigmented, saprophytic organisms called Phaeohyphomycetes
    • Previously called 'Fungi Imperfecti'
  • The two main species of veterinary interest are Microsporum and Trichophton
  • Worldwide
  • They are usually secondary invaders
  • Able to penetrate all layers of skin, but are generally restricted to the keratin layer and its appendages
    • Therefore, most often seen in subcuticular or cutaneous sites
    • Lack of tolerance to body temperature and antifungal activity in serum and body fluids prevent the fungi invading subcutaneously
  • Transmitted by direct or indirect contact
  • Immunuocompromised hosts may develop systemic infections
  • Microsporum - zoophilic
    • Parasites of animals
  • Trichophyton - geophilic
    • Inhabits soil
  • Epidermophyton - anthropophilic
    • Parasites of people
  • Common in many species, especially cats
  • Hot, humid environment predisposes to infection
  • More common in young animals
  • Produce proteolytic enzymes to penetrate surface lipid
  • Fungal hyphae invade keratin -> break into arthrospores
  • Phaeohyphomycosis:
    • Occurs sporadically in cats, horses, cattle, fish, reptiles, amphibians, birds, and rarely in dogs
    • Examples include: Exophiala sp., Phialophora sp., Pseudomicrodochium sp., Bipolaris sp., Moniella sp., Cladosporium sp., Wangiella sp., Curvularia spp., Exserohilum sp., Alternaria sp., Staphylotrichum sp., and Xylohypha sp
    • Culture is necessary for definitive diagnosis

Pathogenesis

  • Superficial perivascular dermatitis -> exocytosis (migration through epidermal layers) -> intracorneal microabscesses
  • Exocytosis -> folliculitis -> furunculosis
  • Highly variable lesions
  • Normal -> eruptive nodular -> pseudomycetoma -> onychomycosis
  • Grossly:
    • Circular or irregular lesion, may coalesce
    • Scaly to crusty patches
    • Alopecia due to broken hair shafts and hairs lost from inflammed follicles
    • Follicular papules and pustules
    • Peripheral red ring (ringworm) due to dead fungi in areas of inflammation at centre of lesions and viable fungi peripherally
  • More common in housed animals, rather than animals turned out to pasture
  • Highest incidence of disease during the winter
    • May resolve spontaneously in the spring and summer

Histology

  • Perifolliculitis, folliculitis or furunculosis
  • Epidermal hyperplasia
  • Intracorneal microabscesses
  • Septate hyphae or spores may be found in stratum corneum and keratin of hair follicles

Diagnosis

  • Wood's Lamp
    • UV light
    • Florourescence if fungi present
  • Samples can be examined in 10-20% KOH for the presence of hyphae or arthrospores
    • Lactophenol Cotton Blue enhances visualisation
  • Sabouraud's Dextrose agar containing cyclohexamide and chloramphenicol at room temperature for a month for culture
  • Dermatophyte Test Medium
    • Saubouraud's Dextrose agar with phenol red indicator
    • Medium changes from yellow to red if fungi present

Treatment

  • Isolation of infected animal
  • Precautions should be taken to prevent human infection
  • Griseofulvin best method of treatment
    • Expensive
    • Oral dosage
    • Prolonged treatment required
  • Whitfield's ointment
    • Salicylic and benzoic acid

Further Links