Feline Calicivirus

From WikiVet English
Revision as of 09:37, 19 January 2016 by BaraStudent (talk | contribs)

(diff) ← Older revision | Approved revision (diff) | Latest revision (diff) | Newer revision → (diff)

Jump to navigation Jump to search


Feline calicivirus infection in a cat, showing ulceration, secondary gingivitis, rhinitis, faucitis and hypersalivation.

Source: Wikimedia Commons; Author: Kalumet (2005)

The normal hosts for this virus are domestic cats and cheetahs. The virus has a high morbidity/low mortality rate, but affected animals can be further compromised by concurrent infection. The incubation period is 2-10 days.

Clinical signs include:

  • Vesicles and ulcers of the oral epithelium (2-5mm)
  • Nasal and ocular discharge
  • Sneezing
  • Anorexia

Variable signs include:

  • Pyrexia
  • Dyspnoea
  • Conjunctivitis
  • Rhinitis
  • Tracheitis
  • Pneumonia

Differential Diagnoses may include:

Recovery can be followed by carrier status


FCV is endemic worldwide. Transmission occurs through direct contact with secretions of carrier cats or indirect contact via drinking bowls, etc. Clinical disease is most frequently seen in kittens; active immunity is generally present in animals over 1 year of age. Antigenic variation means that subclinical reinfections can occur. Calicivirus is one of the agents of cat flu.


A single serotype has been identified which typically has antigenic variations.

Recent strains of the virus have been shown to cause systemic disease, where the initial upper respiratory signs are followed by:

  • Severe pyrexia
  • Oedema, particularly of the head and limbs
  • Skin ulcers
  • Icterus and Petchiae

The mortality rate of recently emerging strains can be as high as 50%, and higher in cats over 1 year of age. Conventional vaccinations are thought to be ineffective against these strains.


Clinical signs are non specific with many other differentials. Nasal, conjunctival, or oropharyngeal swabs can be taken for virus isolation. Cytology of affected cells may demonstrate pyknosis (an irreversible condensation of chromatin in the cell nucleus undergoing necrosis or apoptosis) - feline herpes causes cellular swelling and syncytia formation.


  • Virulent isolate outbreak: quarantine and restrict movement of in contact animals.
  • Prevention: Live or dead vaccines are available that contain broadly cross-reactive strains. Vaccination is often given in combination with feline herpes and panleukopenia virus immunization.

The virus presents a particular concern for catteries due to the epidemiological risk of spread in intensively kept cats.

Feline Calicivirus Learning Resources
VetstreamVetlexicon advert button.png
To reach the Vetstream content, please select
Canis, Felis, Lapis or Equis
FlashcardsFlashcards logo.png
Test your knowledge using flashcard type questions
Feline Medicine Q&A 10
CABICABI logo.jpg
Literature Search
Search for recent publications via CAB Abstract
(CABI log in required)
Feline Calicivirus publications
CABICABI logo.jpg
Full Text Articles
Full text articles available from CAB Abstract
(CABI log in required)
Cats and calicivirus infection - the evolving pattern of disease. Radford, A.; Coyne, K. P.; Dawson, S.; Porter, C. J.; Gaskell, R. M.; Svoboda, M. ; Czech Small Animal Veterinary Association, Prague, Czech Republic, 2006 World Congress Proceedings. 31st World Small Animal Association Congress, 12th European Congress FECAVA, & 14th Czech Small Animal Veterinary Association Congress, Prague, Czech Republic, 11-14 October, 2006, 2006, pp 343-346, 26 ref.

WikiVet® Introduction - Help WikiVet - Report a Problem