Difference between revisions of "Oesophagitis"

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==Typical Signalment==
 
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*Any age group can be affected
 
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*Young animals with congenital hiatal hernias
 
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*Cats are more prone to doxycycline-associated oesophagitis
 
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*Cats suffering from oesophageal stricture
 
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*Anaesthesia
 
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*Poor positioning during anaesthesia
 
 
==Description==  
 
==Description==  
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Oesophagitis in an inflammatory disorder of the oesophagus that usually involves the mucosa but can involve the deeper layers of the submucosa and muscularis. It can take the form of acute or chronic. The disease process occurs after disruption of one of the barrier defence mechanisms and can lead one or several of inflammation, ulceration and erosion of the underlying structures. The most common causes are:
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[[Image:Oesophagitis.jpg|thumb|right|250px|Oesophagitis - Copyright David Walker RVC]]
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*chemical injury following swallowing
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Oesophagitis refers to [[Inflammation - Pathology|inflammation]] of the oesophagus.  This usually involves the '''mucosa''' but can involve the deeper layers of the submucosa and muscularis and it may follow an '''acute''' or '''chronic''' course. The oesophagus is usually protected from physical or chemical damage by mucus (produced by simple tubuloacinar glands along its whole length in dogs and in the rostral portion in cats) and by peristaltic waves and the upper and lower oesophageal sphincters which prevent ingesta or regurgitated material from remaining in contact with the oesophageal wall.  Oesophagitis is a serious condition and, if not treated, it may progress to ulceration, rupture, stricture formation or derangement of normal motility (megaoesophagus). The most common causes are:
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*oesophageal foreign bodies
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*'''Physical Injury'''
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*gastro-oesophageal reflux
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**Ingestion of [[Oesophageal Foreign Body|'''foreign bodies''']] which lodge in the oesophagus.
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**Passage of nasogastric or pharyngostomy '''feeding tubes''' or of large '''endoscopes'''.
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*'''Chemical Injury'''
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**'''Gastro-oesophageal reflux''', which may occur with '''general anaesthesia''' or [[Hiatal Hernia|'''hiatal hernias''']].
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**'''Chronic vomiting'''
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**Ingestion of '''caustic''' or '''irritant substances''', including '''doxycycline''' in cats.
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==Signalment==
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Any age group can be affected and there is usually a history suggestive of a particular cause, such as a recent general anaesthetic or administration of doxycylcine to a cat.
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==Diagnosis==
 
==Diagnosis==
 
===Clinical Signs===
 
===Clinical Signs===
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include:
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Signs include:
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*regurgitation
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*'''Regurgitation''' and '''hypersalivation/ptyalism''' are the most common signs.  Regurgitation can be recognised if the animal shows no abdominal effort (as would occur with vomiting), if the material produced still resembles the food that was eaten.  The material produced is often covered with white foam but bile should never be present.
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*salivation
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*Animals show '''difficulty in swallowing''' and often appear to make '''multiple swallowing efforts''' and to '''extend their necks''' during swallowing.
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*neck extension during swallowing
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*Animals may show signs of '''pain during swallowing''' (odynophagia) and may become '''anorexic'''.
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*odynophagia
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*Like any animals which regurgitate repeatedly, those with oesophagitis may develop '''aspiration pneumonia''' and show signs of pyrexia, coughing, tachypnoea and dyspnoea.
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*food avoidance
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*aspiration pneumonia (wheezes, coughing)
 
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*ptyalism
 
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[[Image:Oesophagitis.jpg|thumb|right|250px|Oesophagitis - Copyright David Walker RVC]]
 
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*anorexia
 
 
===Laboratory Tests===
 
===Laboratory Tests===
 
Generally unremarkable but may show:
 
Generally unremarkable but may show:

Revision as of 10:07, 7 July 2010


 This article is still under construction.



Description

Oesophagitis - Copyright David Walker RVC

Oesophagitis refers to inflammation of the oesophagus. This usually involves the mucosa but can involve the deeper layers of the submucosa and muscularis and it may follow an acute or chronic course. The oesophagus is usually protected from physical or chemical damage by mucus (produced by simple tubuloacinar glands along its whole length in dogs and in the rostral portion in cats) and by peristaltic waves and the upper and lower oesophageal sphincters which prevent ingesta or regurgitated material from remaining in contact with the oesophageal wall. Oesophagitis is a serious condition and, if not treated, it may progress to ulceration, rupture, stricture formation or derangement of normal motility (megaoesophagus). The most common causes are:

  • Physical Injury
    • Ingestion of foreign bodies which lodge in the oesophagus.
    • Passage of nasogastric or pharyngostomy feeding tubes or of large endoscopes.
  • Chemical Injury
    • Gastro-oesophageal reflux, which may occur with general anaesthesia or hiatal hernias.
    • Chronic vomiting
    • Ingestion of caustic or irritant substances, including doxycycline in cats.

Signalment

Any age group can be affected and there is usually a history suggestive of a particular cause, such as a recent general anaesthetic or administration of doxycylcine to a cat.

Diagnosis

Clinical Signs

Signs include:

  • Regurgitation and hypersalivation/ptyalism are the most common signs. Regurgitation can be recognised if the animal shows no abdominal effort (as would occur with vomiting), if the material produced still resembles the food that was eaten. The material produced is often covered with white foam but bile should never be present.
  • Animals show difficulty in swallowing and often appear to make multiple swallowing efforts and to extend their necks during swallowing.
  • Animals may show signs of pain during swallowing (odynophagia) and may become anorexic.
  • Like any animals which regurgitate repeatedly, those with oesophagitis may develop aspiration pneumonia and show signs of pyrexia, coughing, tachypnoea and dyspnoea.

Laboratory Tests

Generally unremarkable but may show:

  • leucocytosis
  • neutrophilia

Diagnostic Imaging

Survey radiographs: generally normal. Signs of aspiration pneumonia may be seen in ventral lung lobes. It can be better differentiated using barium-contrast studies which may show:

  • an irregular mucosal surface
  • narrowing
  • a dilated oesophagus
  • oesophageal hypomotility

Endoscopy: To better diagnose oesophagitis, endoscopy with biopsies can be used. Severe oesophagitis will be seen with an oedematous mucosa that is hyperaemic, ulcerated and actively bleeding, whilst less severe cases may require several mucosal biopsies to diagnose the condition.

Treatment

Mild oesophagitis:

  • withdraw oral food for 2-3 days and manage as an outpatient.

More severe oesophagitis:

  • may need admitting to the hospital, Nil Per Os and animal may require enteral or parenteral nutritional support.

Drugs:

  • oral sucralfate suspension
  • gastric acid secretory inhibitors (e.g. ranitidine, omeprazole) can be useful in cases of gastro-oesophageal reflux
  • broad spectrum antibiotics in animals with sever oesophagitis or aspiration pneumonia
  • analgesics

Prognosis

Mild oesophagitis has a good prognosis whereas ulcerative oesophagitis and animals suffering from aspiration pneumonia have a more guarded prognosis.

References

Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA

Merck & Co (2008) The Merck Veterinary Manual

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