Difference between revisions of "Pemphigus"

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*Types:
 
*Types:
 
**'''Pemphigus vulgaris'''
 
**'''Pemphigus vulgaris'''
 +
***'''Pathogenesis:''' [[Type II Hypersensitivity|Type II hypersensitivity]]
 
***Rare, severe form
 
***Rare, severe form
 
***Cats and dogs
 
***Cats and dogs
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[[Category:Oral Cavity - Immune Mediated Pathology]]
 
[[Category:Oral Cavity - Immune Mediated Pathology]]
 
[[Category:To_Do_-_Clinical]]
 
[[Category:To_Do_-_Clinical]]
 +
[[Category:Antibody Mediated Autoimmune Diseases]]
 +
[[Category:To Do - Blood]]

Revision as of 17:03, 22 February 2011

  • Blistering diseases
  • Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
  • Types:
    • Pemphigus vulgaris
      • Pathogenesis: Type II hypersensitivity
      • Rare, severe form
      • Cats and dogs
      • Vesicles or bullae -> erosions and ulcers
      • Involves oral cavity, mucocutaneous junctions and skin
      • Microscopically:
        • Suprabasilar vesiculation and row of basal cells adhering to basement membrane
        • Superficial perivascular dermatitis
    • Pemphigus vegetans
      • Rare
      • Dogs
      • Involves the trunk
      • Mild version of P. vulgaris
      • Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
    • Pemphigus foliaceus
      • More common
      • Cats, dogs, horses, goats
      • Localised lesions or generalised
      • Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
      • Microscopically:
        • Acantholytic cells
        • Subcorneal or intragranular pustules
        • In third of equine or canine cases eosinophils are predominant
    • Pemphigus erythematosus
      • Cats and dogs
      • Mild form of P. foliaceus
      • Usually involves only face and external ears


Autoimmune

  • Occasionally see vesicles on the oral mucosa. associated with autoimmune diseases such as Pemphigus vulgaris.