Difference between revisions of "Pemphigus"
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*Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles | *Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles | ||
*Types: | *Types: | ||
| − | **'''Pemphigus vulgaris''' | + | **'''[[Pemphigus Vulgaris|Pemphigus vulgaris]]''' |
***'''Pathogenesis:''' [[Type II Hypersensitivity|Type II hypersensitivity]] | ***'''Pathogenesis:''' [[Type II Hypersensitivity|Type II hypersensitivity]] | ||
***Rare, severe form | ***Rare, severe form | ||
Revision as of 13:20, 27 April 2011
- Blistering diseases
- Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
- Types:
- Pemphigus vulgaris
- Pathogenesis: Type II hypersensitivity
- Rare, severe form
- Cats and dogs
- Vesicles or bullae -> erosions and ulcers
- Involves oral cavity, mucocutaneous junctions and skin
- Microscopically:
- Suprabasilar vesiculation and row of basal cells adhering to basement membrane
- Superficial perivascular dermatitis
- Pemphigus vegetans
- Rare
- Dogs
- Involves the trunk
- Mild version of P. vulgaris
- Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
- Pemphigus foliaceus
- More common
- Cats, dogs, horses, goats
- Localised lesions or generalised
- Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
- Microscopically:
- Acantholytic cells
- Subcorneal or intragranular pustules
- In third of equine or canine cases eosinophils are predominant
- Pemphigus erythematosus
- Cats and dogs
- Mild form of P. foliaceus
- Usually involves only face and external ears
- Pemphigus vulgaris
Autoimmune
- Occasionally see vesicles on the oral mucosa. associated with autoimmune diseases such as Pemphigus vulgaris.