Negative feedback occurs directly, with increased GH levels causing the hypothalamus to secrete GHIH to inhibit further GH secretion. In addition, negative feedback occurs via the liver. GH causes the liver to secrete [[IGF-1 - Anatomy & Physiology|IGF-1]] which directly decreases GH secretion from the pituitary, and also acts on the hypothalamus to secrete GHIH to further decrease secretion. | Negative feedback occurs directly, with increased GH levels causing the hypothalamus to secrete GHIH to inhibit further GH secretion. In addition, negative feedback occurs via the liver. GH causes the liver to secrete [[IGF-1 - Anatomy & Physiology|IGF-1]] which directly decreases GH secretion from the pituitary, and also acts on the hypothalamus to secrete GHIH to further decrease secretion. |