Changes

Regulation of GH secretion is complex. The Hypothalamus produces the stimulatory ''Growth Hormone Releasing Hormone (GHRH)'' and the inhibitory ''Growth Hormone Inhibitory Hormone (GHIH)'' also known as Somatostatin, which have their effects directly on the anterior pituitary gland.

Regulation of GH secretion is complex. The Hypothalamus produces the stimulatory ''Growth Hormone Releasing Hormone (GHRH)'' and the inhibitory ''Growth Hormone Inhibitory Hormone (GHIH)'' also known as Somatostatin, which have their effects directly on the anterior pituitary gland.

Ghrelin, from the [[Gut - Anatomy & Physiology|stomach]] stimulates the pituitary gland to secrete further GH.  

Ghrelin, from the [[Endocrine System - Gut - Anatomy & Physiology|stomach]] stimulates the pituitary gland to secrete further GH.  

Negative feedback occurs directly, with increased GH levels causing the hypothalamus to secrete GHIH to inhibit further GH secretion. In addition, negative feedback occurs via the liver. GH causes the liver to secrete [[IGF-1 - Anatomy & Physiology|IGF-1]] which directly decreases GH secretion from the pituitary, and also acts on the hypothalamus to secrete GHIH to further decrease secretion.

Negative feedback occurs directly, with increased GH levels causing the hypothalamus to secrete GHIH to inhibit further GH secretion. In addition, negative feedback occurs via the liver. GH causes the liver to secrete [[IGF-1 - Anatomy & Physiology|IGF-1]] which directly decreases GH secretion from the pituitary, and also acts on the hypothalamus to secrete GHIH to further decrease secretion.