Difference between revisions of "Ragwort Toxicity"
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{| cellpadding="10" cellspacing="0" border="1" | {| cellpadding="10" cellspacing="0" border="1" | ||
| − | | Also known as: | + | |Also known as: |
| − | | '''Senecio jacobea<br> | + | |'''Senecio jacobea<br> |
|-} | |-} | ||
| + | |||
| + | ==Description== | ||
| + | |||
| + | ==Signalment== | ||
| + | |||
| + | ==Diagnosis== | ||
| + | |||
| + | ===Clinical signs=== | ||
| + | |||
| + | ===Cytology=== | ||
| + | |||
| + | ===Biopsy=== | ||
| + | |||
| + | ==Treatment== | ||
| + | |||
| + | ==Prognosis== | ||
| + | |||
| + | ==References== | ||
| + | * Knottenbelt, D.C. '''A Handbook of Equine Medicine for Final Year Students''' ''University of Liverpool'' | ||
| + | *Rose, R. J. and Hodgson, D. R. (2000) '''Manual of Equine Practice''' (Second Edition) Sauders. | ||
| + | |||
==Hepatotoxicity== | ==Hepatotoxicity== | ||
| − | + | plant toxin ingested over a long period of time | |
*livestock | *livestock | ||
**cattle and horses are more susceptible than sheep | **cattle and horses are more susceptible than sheep | ||
| Line 21: | Line 42: | ||
*it is likely that the vascular component of the attempted repair of the chronic damage by fibrosis (really a type of granulation tissue) aids the shunting from the portal triads to the central vein and thereby bypassing the hepatocytes | *it is likely that the vascular component of the attempted repair of the chronic damage by fibrosis (really a type of granulation tissue) aids the shunting from the portal triads to the central vein and thereby bypassing the hepatocytes | ||
*other plant and fungal toxins perform in the same way | *other plant and fungal toxins perform in the same way | ||
| + | |||
====Gross==== | ====Gross==== | ||
*slightly enlarged [[Liver - Anatomy & Physiology|liver]] | *slightly enlarged [[Liver - Anatomy & Physiology|liver]] | ||
*pale in colour | *pale in colour | ||
*very firm to section | *very firm to section | ||
| + | |||
====Microscopically==== | ====Microscopically==== | ||
*necrosis | *necrosis | ||
*haemorrhage | *haemorrhage | ||
*diffuse fibrosis | *diffuse fibrosis | ||
| + | |||
[[Category:Hepatotoxicity, Chronic]][[Category:Horse]][[Category:Sheep]] | [[Category:Hepatotoxicity, Chronic]][[Category:Horse]][[Category:Sheep]] | ||
[[Category:To_Do_- lizzyk]] | [[Category:To_Do_- lizzyk]] | ||
Revision as of 15:57, 25 July 2010
 |
This article is still under construction. |
Description
Signalment
Diagnosis
Clinical signs
Cytology
Biopsy
Treatment
Prognosis
References
- Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
- Rose, R. J. and Hodgson, D. R. (2000) Manual of Equine Practice (Second Edition) Sauders.
Hepatotoxicity
plant toxin ingested over a long period of time
- livestock
- cattle and horses are more susceptible than sheep
- livestock will not normally eat the fresh plant
- most cases arise in horses and cattle consuming ragwort in hay or silage
- pyrrolizidine alkaloids
- toxic principle converted in the body to the toxic intermediate pyrroles and their esters
- cause intitial and continued damage to hepatocytes
- have an anti-mitotic effect whilst allowing continued synthesis within the cell and its nucleus
- causes a marked increase in the size of parenchymal cells, a phenomenon termed 'megalocytosis'
- these very enlarged hepatocytes can be up to 20 times bigger
- the enlarged cells are closely apposed so that the sinusoids may not be evident
- it is likely that the vascular component of the attempted repair of the chronic damage by fibrosis (really a type of granulation tissue) aids the shunting from the portal triads to the central vein and thereby bypassing the hepatocytes
- other plant and fungal toxins perform in the same way
Gross
- slightly enlarged liver
- pale in colour
- very firm to section
Microscopically
- necrosis
- haemorrhage
- diffuse fibrosis
| Also known as: | Senecio jacobea |