Difference between revisions of "Theileria"

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m (Text replace - 'Lymphocytes - WikiBlood' to 'Lymphocytes')
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*Lymphoid depletion
 
*Lymphoid depletion
**[[Lymphocytes - WikiBlood|Lymphocytes]] killed
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**[[Lymphocytes|Lymphocytes]] killed
 
**Decreases lymphopoiesis
 
**Decreases lymphopoiesis
 
**Occurs in week 3
 
**Occurs in week 3

Revision as of 12:38, 12 June 2010

Theileria parva Life Cycle Diagram - Dennis Jacobs & Mark Fox RVC
File:Lymph node smear East Coast Fever.jpg
Lymph node smear of a cow with East Coast Fever - Drs. Elizabeth Howerth and Bruce LeRoy, Department of Pathology, UGA College of Veterinary Medicine
File:H and E stain brain East Coast Fever.jpg
H and E stain of brain and meningal vessels of a cow with East Coast Fever - Drs. Elizabeth Howerth and Bruce LeRoy, Department of Pathology, UGA College of Veterinary Medicine
Theileria cervi (deer) - Drs. Elizabeth Howerth and Bruce LeRoy, Department of Pathology, UGA College of Veterinary Medicine
  • Main species of veterinary importance is Theileria parva
  • Other Theileria species cause production losses in cattle and sheep in the Middle East, Mediterranean and in Northern Africa

Life Cycle

  • Incubation phase lasts 1 week
  • Lymphoblast proliferation
    • Local lymph node first infected then spreads through body
    • Occurs in week two
  • Lymphoid depletion
    • Lymphocytes killed
    • Decreases lymphopoiesis
    • Occurs in week 3
  • Total incubation period takes about 18 days

Diagnosis

  • Examine Giemsa stained smears of:
    • Local lymph node aspirated for schizonts
    • Blood smears for piroplasms in red blood cells
  • Post-mortem

Control

  • Current vaccination is live unattentuated
    • Contains frozen stabilate of ground up tick gut containing infective sporozoites
    • Long lasting oxytetracycline administered at the same time to slow down schizogony giving the immune response time to develop