Histopathology of lesions revealed '''squamous epithelial swelling, pyknosis and karryorhexis'''. As cells died, the virus spread to neighbouring cells. Epithelial cells that were left intact usually showed evidence of '''degeneration and intracellular oedema'''. Haemorrhage and oedema were also seen in the subcutaneous tissues. The '''malphigian layer of the dermis''' where the virus primarily replicated became '''infiltrated with neutrophils and was thus weakened and oedematous, causing the upward displacement of the epidermis above it and thus the characteristic vesicle.''' | Histopathology of lesions revealed '''squamous epithelial swelling, pyknosis and karryorhexis'''. As cells died, the virus spread to neighbouring cells. Epithelial cells that were left intact usually showed evidence of '''degeneration and intracellular oedema'''. Haemorrhage and oedema were also seen in the subcutaneous tissues. The '''malphigian layer of the dermis''' where the virus primarily replicated became '''infiltrated with neutrophils and was thus weakened and oedematous, causing the upward displacement of the epidermis above it and thus the characteristic vesicle.''' |