Difference between revisions of "Border Disease Virus"
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*Tropism: fetal lymphoid tissue, hair follicles, and CNS | *Tropism: fetal lymphoid tissue, hair follicles, and CNS | ||
*Causes '''abortion''' or '''weak lambs''' | *Causes '''abortion''' or '''weak lambs''' | ||
| − | *'''Hairy shaker lambs''': born with [[ | + | *'''Hairy shaker lambs''': born with [[Hypertrichosis|hair instead of wool]] |
**'''Immunotolerant''' status when exposed in mid-third of gestation | **'''Immunotolerant''' status when exposed in mid-third of gestation | ||
**Also associated with '''cerebellar hypoplasia''' | **Also associated with '''cerebellar hypoplasia''' | ||
Revision as of 15:33, 21 February 2011
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This article is still under construction. |
Hosts
- Sheep
- Goats
Pathogenesis
- Tropism: fetal lymphoid tissue, hair follicles, and CNS
- Causes abortion or weak lambs
- Hairy shaker lambs: born with hair instead of wool
- Immunotolerant status when exposed in mid-third of gestation
- Also associated with cerebellar hypoplasia
Epidemiology
- Can cause significant problems to a flock
- First reported on Welsh borders
Diagnosis
- Clinical: abortion and hairy shaker lambs
- Confirmation by serology: ELISA for virus antigen
Control
- No UK vaccine
- Vaccines available in USA and Europe
- Blood testing sheep can aid in culling seropositive ewes
A pestivirus causing abortion often of brown, anasarcous foetus which may be mistaken for scouring if early in pregnancy (ewe barren at lambing time). Live lambs are born early hairy shakers small, weak, hairy lambs with skeletal abnormalities.