Difference between revisions of "Bovine Leukocyte Adhesion Deficiency"

Revision as of 18:19, 11 March 2011

Also known as BLAD

Introduction

This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent pneumonia. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.

Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.

Clinical Signs

Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.

Diagnosis

There are tests available in the US to diagnose heterozygous carriers and homozygous calves.

Control

Test the herd and eliminate carrier animals.

Literature Search

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).

Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review. Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. - Full Text Article

References

Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing

Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences

@@ Line 1: / Line 1: @@
-Also known as "BLAD".
+{{review}}
-== Introduction<br> ==
+Also known as '''''BLAD'''''
-This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is is characterised by premature death and chronic bacterial infections such as recurrent pneumonia. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
+== Introduction ==
-Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.<br>
+This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent [[:Category:Pneumonia|pneumonia]]. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
-<br>
+Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.
-== Clinical Signs<br> ==
-Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasulitis. The infection will always reappear, even following doses usually high enough to cure the infection. <br>
+== Clinical Signs ==
-<br>
+Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.
-== Diagnosis<br> ==
-There are tests avaliable in the US to diagnose heterozygous carriers and homozygous calves.<br>
+== Diagnosis ==
-<br>
+There are tests available in the US to diagnose heterozygous carriers and homozygous calves.
-== Control<br> ==
-Test the herd and eliminate carrier animals.<br>
+== Control ==
-<br>
+Test the herd and eliminate carrier animals.
-== References<br> ==
-Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing<br>
+== Literature Search ==
-Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences<br>
+[[Image:CABI logo.jpg|left|90px]]
+<br> Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation). <br><br><br> [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. - '''Full Text Article''']
-== Literature Search ==
+== References ==
+Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing
+Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences
-[[Image:CABI logo.jpg|left|90px]]
-<br> Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation). <br><br><br> [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. - '''Full Text Article''']
-[[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:To_Do_-_Blood]] [[Category:To_Do_-_Review]]
+[[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:Expert_Review - Farm Animal]]