Difference between revisions of "Bovine Leukocyte Adhesion Deficiency"
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| − | Also known as | + | {{OpenPagesTop}} |
| + | Also known as '''''BLAD''''' | ||
| − | == Introduction | + | == Introduction == |
| − | This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It | + | This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent [[:Category:Pneumonia|pneumonia]]. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation. |
| − | Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old. | + | Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old. |
| − | + | == Clinical Signs == | |
| − | + | Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection. | |
| − | + | == Diagnosis == | |
| − | + | There are tests available in the US to diagnose heterozygous carriers and homozygous calves. | |
| − | == | + | == Control == |
| − | + | Test the herd and eliminate carrier animals. | |
| − | + | {{Learning | |
| + | |full text = [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref.] | ||
| + | }} | ||
| − | |||
| − | + | == References == | |
| − | + | Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing | |
| − | + | Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences | |
| − | |||
| − | + | {{review}} | |
| + | {{OpenPages}} | ||
| − | + | [[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:Expert_Review - Farm Animal]] | |
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| − | [[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category: | ||
Latest revision as of 19:02, 26 July 2012
Also known as BLAD
Introduction
This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent pneumonia. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.
Clinical Signs
Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.
Diagnosis
There are tests available in the US to diagnose heterozygous carriers and homozygous calves.
Control
Test the herd and eliminate carrier animals.
| Bovine Leukocyte Adhesion Deficiency Learning Resources | |
|---|---|
 Full text articles available from CAB Abstract (CABI log in required) |
Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review. Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. |
References
Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing
Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences
 |
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
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