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Bovine Leukocyte Adhesion Deficiency (view source)
Revision as of 19:02, 26 July 2012
, 19:02, 26 July 2012no edit summary
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Also known as '''''BLAD'''''
== Introduction ==
[[Category:Primary Innate Immunity Deficiencies]]
[[Category:Cattle]]
This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent [[:Category:Pneumonia|pneumonia]]. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
[[Category:To Do - Blood]]
Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.
== Clinical Signs ==
Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.
== Diagnosis ==
There are tests available in the US to diagnose heterozygous carriers and homozygous calves.
== Control ==
Test the herd and eliminate carrier animals.
{{Learning
|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref.]
}}
== References ==
Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing
Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences
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[[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:Expert_Review - Farm Animal]]