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==Mechanism of Action==
==Mechanism of Action==
The combination of sulphonamide and trimethoprim means that the bacterial nucleotide sythesis pathway is attacked at two seperate points. This produces a bactericidal, time-dependent killing affect. To find out how sulphonamides work click [[sulphonamides|here]] and to discover the same about trimethoprim click [[trimethoprim|here]].
The combination of sulphonamide and trimethoprim means that the bacterial nucleotide sythesis pathway is attacked at two seperate points. This produces a bactericidal, time-dependent killing affect. To find out how sulphonamides work click [[sulphonamides|here]] and to discover the same about trimethoprim click [[Trimethoprim - Dihydrofolate Reductase Inhibitors|here]].
==Spectrum of Activity==
==Spectrum of Activity==
They all have good tissue penetration and will readily cross the blood brain barrier. As resistance is now a problem with these drugs their efficacy is starting to become limited.
They all have good tissue penetration and will readily cross the blood brain barrier. As resistance is now a problem with these drugs their efficacy is starting to become limited.
==Side Effects and Contraindications==
==Side Effects and Contraindications==
These drugs are relatively safe and have wide safety margins in all species except in cats. Again look at the individual drug combinations for specific mixture side-effects. Concern has been noted about immune-mediated reactions in dogs.
{{Learning
|Vetstream = [https://www.vetstream.com/canis/Content/Generic/gen00290.asp Trimethoprim]}}