Changes

<p>Part of the [[Lymphatic System - Anatomy & Physiology|lymphatic system]], the body contains hundreds of lymph nodes of varying size (1-20mm) and these are located along the routes of [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. They are found throughout the body but are more concentrated in the axilla, groin and mesenteries. Lymph nodes act as a filter for the lymph removing antigens and releasing immune-competent cells and immunoglobulins.</p>

<p>Part of the [[Lymphatic System - Anatomy & Physiology|lymphatic system]], the body contains hundreds of lymph nodes of varying size (1-20mm) and these are located along the routes of [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. They are found throughout the body but are more concentrated in the axilla, groin and mesenteries. Lymph nodes act as a filter for the lymph removing antigens and releasing immune-competent cells and immunoglobulins.</p>

==Development==

==Development==

<p>Lymph nodes develop from lateral plate mesoderm in paired sacs from [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. These sacs undergo remodelling and endothelial and mesenchymal outgrowths form the meshwork of channels and spaces that produces the cortex-medulla structure. Lymphocytes then populate the cortex and medulla. The sub-capular sinus is a remainder of the [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessel]].</p>

<p>Lymph nodes develop from lateral plate mesoderm in paired sacs from [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. These sacs undergo remodelling, and endothelial and mesenchymal outgrowths form the meshwork of channels and spaces that produces the cortex-medulla structure. Lymphocytes then populate the cortex and medulla. The sub-capular sinus is a remainder of the [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessel]].</p>

 

==Structure==

==Structure==

[[Image:LH_Lymph_Node_Follicles_Histology.jpg|thumb|150px|right|<p>'''Primary & secondary follicles'''</p>^{©Nottingham Uni 2008}]]

[[Image:LH_Lymph_Node_Follicles_Histology.jpg|thumb|150px|right|<p>'''Primary & secondary follicles'''</p>^{©Nottingham Uni 2008}]]