Difference between revisions of "Adaptive Immunity to Viruses"
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m (Text replace - "[[MHC - WikiBlood#" to "[[Major Histocompatability Complexes#") |
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*[[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells | *[[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells | ||
**Main cells involved in the immune response to '''intracellular''' virus infection | **Main cells involved in the immune response to '''intracellular''' virus infection | ||
| − | **Recognition of [[ | + | **Recognition of [[Major Histocompatability Complexes#MHC I|MHC I]]-peptide complex |
**Infected cells are killed by apoptosis | **Infected cells are killed by apoptosis | ||
***Perforin and granzymes activate the caspase cascade | ***Perforin and granzymes activate the caspase cascade | ||
Revision as of 14:22, 16 August 2010
Humoral
- Production of neutralising antibody
- Antibody-dependent cell mediated cytotoxicity (ADCC)
Antibody-labelled cells can be targeted by NK Cells as another defence against viral infection. Antibody produced against viral protein can attach to infected cells during their budding phase, which effectively labels them for NK targeting. NK cells express Fcγ receptors with which to detect such cells. Once activated, they release a host of enzymes to induce apoptosis of the budding cell.
Cell-Mediated
- CD8+ T-cell mediated killing of virus infected cells
- Main cells involved in the immune response to intracellular virus infection
- Recognition of MHC I-peptide complex
- Infected cells are killed by apoptosis
- Perforin and granzymes activate the caspase cascade
- Fas-ligand triggers the Fas-mediated apoptosis pathway
- Cytotoxic cytokines (especially TNF-α & TNF-β lymphotoxin) act on TNF receptors to induce programmed cell death
Also see Immunity to Viruses