Difference between revisions of "B cells"

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Also known as '''''B lymphocytes
 
Also known as '''''B lymphocytes
<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the '''adaptive immune system'''. They represent 20-30% of circulating lymphocytes.
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<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the [[:Category:Adaptive Immune System|'''adaptive immune system''']]. They represent 20-30% of circulating lymphocytes.
 
B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody  [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>
 
B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody  [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>
 
<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>
 
<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>

Revision as of 09:49, 27 September 2010

B Cells in Lymph node

©RVC 2008

Also known as B lymphocytes

So named as they were initially found in the Bursa of Fabricius, B cells produce antibodies (Ig’s) and are associated with humoral immunity (T cells are part of the cell-mediated immune response), and are an integral part of the adaptive immune system. They represent 20-30% of circulating lymphocytes. B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody IgM when the B cell is immature, changing to IgD when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.

Under antigenic stimulation B cells differentiate into plasma cells and memory cells.

B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T cells on MHC II.