Changes

Testosterone inhibits the secretion of GnRH from the hypothalamus and therefore secretion of LH from the pituitary gland. if the testes are removed via castration, blood concentrations of LH and FSH will increase as there is only limited negative feedback.

Testosterone inhibits the secretion of GnRH from the hypothalamus and therefore secretion of LH from the pituitary gland. if the testes are removed via castration, blood concentrations of LH and FSH will increase as there is only limited negative feedback.

===Effects of Male Sex Hormones===

====Effects of Male Sex Hormones====

Testosterone plays a crucial role in the development of male sex organs during fetal growth where increased production of testosterone causes penis growth and development of accessory sex glands during puberty. Testosterone also affects a number of other characteristics of the male, often called the "secondary sex characteristics". Testosterone is able to bind to receptors in the cytosol of cells in the same manner as other steroid hormones and these hormone-receptor complexes are then able to bind to DNA in the nucleus resulting in alterations in the level of transcription of specific genes.  

Testosterone plays a crucial role in the development of male sex organs during fetal growth where increased production of testosterone causes penis growth and development of accessory sex glands during puberty. Testosterone also affects a number of other characteristics of the male, often called the "secondary sex characteristics". Testosterone is able to bind to receptors in the cytosol of cells in the same manner as other steroid hormones and these hormone-receptor complexes are then able to bind to DNA in the nucleus resulting in alterations in the level of transcription of specific genes.  

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