Changes

'''Life Cycle'''

'''Life Cycle'''

*Large schizonts of ''C. felis'' develop in [[Macrophages - WikiBlood|macrophages]]

*Large schizonts of ''C. felis'' develop in [[Macrophages|macrophages]]

**In Theileria the exoerythrocytic stage occurs primarily within [[Lymphocytes - WikiBlood|lymphocytes]]

**In Theileria the exoerythrocytic stage occurs primarily within [[Lymphocytes - Introduction|lymphocytes]]

*In ''C. felis'', schizonts develop within mononuclear phagocytes, initially as indistinct vesicular structures and later as large, distinct nucleated schizonts that actively undergo division by true schizogony and binary fission

*In ''C. felis'', schizonts develop within mononuclear phagocytes, initially as indistinct vesicular structures and later as large, distinct nucleated schizonts that actively undergo division by true schizogony and binary fission

*Merozoites are then believed to enter erythrocytes to form the intraerythrocytic stage

*Merozoites are then believed to enter erythrocytes to form the intraerythrocytic stage

   

   

*Merozoites appear in [[Macrophages - WikiBlood|macrophages]] one to three days before they are observed in [[Erythrocytes - WikiBlood|erythrocytes]]

*Merozoites appear in [[Macrophages|macrophages]] one to three days before they are observed in [[Erythrocytes|erythrocytes]]

   

   

'''Pathogenicity'''

'''Pathogenicity'''

*Gross findings include pale or icteric mucous membranes, petechiae and ecchymoses in the [[Lungs - Anatomy & Physiology|lung]], [[Heart - Anatomy & Physiology|heart]], [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and on mucous membranes, splenomegaly, lymphadenomegaly, and hydropericardium

*Gross findings include pale or icteric mucous membranes, petechiae and ecchymoses in the [[Lungs - Anatomy & Physiology|lung]], [[Heart - Anatomy & Physiology|heart]], [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and on mucous membranes, splenomegaly, lymphadenomegaly, and hydropericardium

   

   

*Microscopically, numerous large schizonts are present within the cytoplasm of endothelial-associated [[Macrophages - WikiBlood|macrophages]]

*Microscopically, numerous large schizonts are present within the cytoplasm of endothelial-associated [[Macrophages|macrophages]]

**Infected macrophages become markedly enlarged (up to 75μm) and may occlude the lumen of numerous vessels of many tissues, in particular the [[Lungs - Anatomy & Physiology|lungs]]

**Infected macrophages become markedly enlarged (up to 75μm) and may occlude the lumen of numerous vessels of many tissues, in particular the [[Lungs - Anatomy & Physiology|lungs]]

**Minimal inflammatory reaction is present in tissues  

**Minimal inflammatory reaction is present in tissues  

'''Diagnosis'''

'''Diagnosis'''

*Merozoites within [[Erythrocytes - WikiBlood|erythrocytes]], best seen on peripheral blood or tissue impressions, are variable in morphology and can occur as round, oval, or signet ring-shaped bodies  

*Merozoites within [[Erythrocytes|erythrocytes]], best seen on peripheral blood or tissue impressions, are variable in morphology and can occur as round, oval, or signet ring-shaped bodies  

**Are 1-5 micrometers in diameter  

**Are 1-5 micrometers in diameter  

**Small, peripherally placed basophilic nucleus

**Small, peripherally placed basophilic nucleus

**Unlike ''Cytauxzoon'', ''babesiosis'' and ''hemobartonellosis'' do not have a tissue stage of infection

**Unlike ''Cytauxzoon'', ''babesiosis'' and ''hemobartonellosis'' do not have a tissue stage of infection

    

    

*Differential diagnosis for the tissue phase of ''cytauxzoonosis'' includes other small (less than 5 μm), intrahistiocytic organisms such as ''Toxoplasma'', ''Leishmania'' and ''Histoplasma''[[Category:Piroplasmida]]

*Differential diagnosis for the tissue phase of ''cytauxzoonosis'' includes other small (less than 5 μm), intrahistiocytic organisms such as ''Toxoplasma'', ''Leishmania'' and ''Histoplasma''

 

 

[[Category:Piroplasmida]]

 

[[Category:To_Do_-_Parasites]]