Difference between revisions of "Type II Hypersensitivity"
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[[Adaptive Immune System - WikiBlood#Adaptive Immunity to Viruses|1. Antibody dependent cell cytotoxicity (ADCC)]] | [[Adaptive Immune System - WikiBlood#Adaptive Immunity to Viruses|1. Antibody dependent cell cytotoxicity (ADCC)]] | ||
| − | * [[Autoimmune diseases - WikiClinical# | + | * [[Autoimmune diseases - WikiClinical#5. Pemhigus Vulgaris|Pemphigus vulgaris]] |
* [[Autoimmune diseases - WikiClinical#4. Bullous Pemphigoid|Bullous pemphigoid]] | * [[Autoimmune diseases - WikiClinical#4. Bullous Pemphigoid|Bullous pemphigoid]] | ||
Revision as of 16:36, 29 September 2008
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Introduction
Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.
Mechanism
"Neutralisation" blockade of receptors:
- Antibodies attach to receptors which prevents other molecules attaching.
- For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur.
Immunological attack on target cells, destroying them by (see diagram):
1. Antibody dependent cell cytotoxicity (ADCC)
2. Complement mediated lysis
- Self RBC antigen:
- Foreign RBC:
- Blood transfusion reaction
- Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)
- RBC parasite:
- Feline infectious anaemia (Mycoplasma haemofelis)
3. Phagocytosis