Difference between revisions of "Penicillins"

From WikiVet English
Jump to navigation Jump to search
Line 9: Line 9:
  
  
[[Image: Penicillin.png|right|250px|The Core Structure of Penicillin]]
+
[[Image: Penicillin.png|thumb|right|250px|The Core Structure of Penicillin]]
 
==Mechanism of Action==
 
==Mechanism of Action==
  

Revision as of 13:51, 22 October 2008



WikiDrugsWikiDrugs Banner.png
WIKIDRUGS
ANTIBIOTICS



The Core Structure of Penicillin

Mechanism of Action

Penicillins are β-Lactam antibiotics. This means that they interfere with the synthesis of peptidoglycan, a crucial component of the bacterial cell wall. Penicillins bind to proteins on the bacteria and then inhibit a transpeptidation enzyme, whose role is to cross-link peptides attached to the peptiglycan backbone. This weakens the bacterial cell wall integrity.

The penicillins also inactivate an inhibitor of autolytic enzymes present in the cell wall, thus resulting in lysis of the bacterium.

Spectrum of Activity

Pharmacokinetic Considerations

Side Effects and Contraindications

Potential Uses