Difference between revisions of "Coccidioidomycosis"
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(Created page with 'thumb|right|200px|Coccidioidomycosis spherule histopathology - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath *''Coc…') |
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*Causes nodule or granuloma formation | *Causes nodule or granuloma formation | ||
**Localised | **Localised | ||
− | **Gross lesions resemble [[ | + | **Gross lesions resemble [[Mycobacterium bovis|Tb]] in cattle as are usually seen in the bronchial and mediastinal [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and occasionally [[Lungs - Anatomy & Physiology|lungs]] |
**Dissemination can occur, especially in primates and dogs, to the [[Lungs - Anatomy & Physiology|lungs]], [[Liver - Anatomy & Physiology|liver]], [[Spleen - Anatomy & Physiology|spleen]], [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|brain]] and [[Bones and Cartilage - Anatomy & Physiology|bones]] | **Dissemination can occur, especially in primates and dogs, to the [[Lungs - Anatomy & Physiology|lungs]], [[Liver - Anatomy & Physiology|liver]], [[Spleen - Anatomy & Physiology|spleen]], [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|brain]] and [[Bones and Cartilage - Anatomy & Physiology|bones]] | ||
Revision as of 11:14, 14 May 2010
- Coccidioides immitis
- Ocurs in the soil
- Respiratory infections
- Most commonly seen following dust storms
- Occurs in arid regions
- E.g. South West USA and Mexico
- Non-contageous, systemic mycosis
- Affects dogs, cattle, sheep and humans
- Mainly affects the lungs
- Dissemination can occur to other organs
- Causes nodule or granuloma formation
- Thick-walled spherules in tissue
- Large sporangia burst leaving 'ghost' spherules
- Saprophytic phase consists of coarse, septate, branching hyphae which fragment into thick-walled, barrel-shaped arthrospores which alternate with empty cells
- Stained by Lactose Phenol Cotton Blue
- Grows on Sabouraud's Dextrose agar and Blood agar
- Flat, moist colonies which develop a coarse, cotton-like aerial mycelium which varies from white to brown in colour
- Complement fixation test, latex agglutination and immunodiffusion tests can all be used
- A positive skin test indicates exposure