Changes

*'''Urinary tract signs''', including dysuria, stranguria, haematuria and pollakiuria.  These signs occur because an increased blood ammonia concentration decreases the ability of enzymes to convert [[Urate Metabolism - Pathology|uric acid]] to allantoin, resulting in urate urolithiasis and urethral obstruction.  Ammonium biurate are the most common uroliths to be formed.

*'''Urinary tract signs''', including dysuria, stranguria, haematuria and pollakiuria.  These signs occur because an increased blood ammonia concentration decreases the ability of enzymes to convert [[Urate Metabolism - Pathology|uric acid]] to allantoin, resulting in urate urolithiasis and urethral obstruction.  Ammonium biurate are the most common uroliths to be formed.

*'''Polyuria and polydipsia''' occur for reasons that are not fully understood.  Urea synthesis is reduced in animals with PSS (because ammonia is not taken up by the liver in the normal way) and a reduction in the urea concentration of the renal medulla reduces the ability of the kidney to concentrate urine.  The hypofunctional liver probably also degrades cortisol at a reduced rate, increasing the circulating concentration of this diuretic hormone.   

*'''Polyuria and polydipsia''' occur for reasons that are not fully understood.  Urea synthesis is reduced in animals with PSS (because ammonia is not taken up by the liver in the normal way) and a reduction in the urea concentration of the renal medulla reduces the ability of the kidney to concentrate urine.  The hypofunctional liver probably also degrades cortisol at a reduced rate, increasing the circulating concentration of this diuretic hormone.   

*Intermittent '''gastro-intestinal signs''' such as [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Diarrhoea|diarrhoea]].

*Intermittent '''gastro-intestinal signs''' such as [[Vomiting|vomiting]] and [[Diarrhoea|diarrhoea]].

*'''Ascites''' may occur due to [[Hypoalbuminaemia|hypoalbuminaemia]].

*'''Ascites''' may occur due to [[Hypoalbuminaemia|hypoalbuminaemia]].

*'''Bleeding tendencies''' due to coagulopathy, but this condition is often subclinical.

*'''Bleeding tendencies''' due to coagulopathy, but this condition is often subclinical.