Difference between revisions of "Cytology Q&A 06"

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'''A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (29a) (Wright–Giemsa, ×25).'''
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'''A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (Wright–Giemsa, ×25).'''
  
 
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*Abundant punctate vacuoles are also noted in the background.  
 
*Abundant punctate vacuoles are also noted in the background.  
 
*The cytological interpretation is vacuolar degeneration compatible with hepatic lipidosis.
 
*The cytological interpretation is vacuolar degeneration compatible with hepatic lipidosis.
|l2=Hepatic Lipidosis#Diagnosis
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|l2=Hepatic Lipidosis#Pathology
 
|q3=List the differentials for your diagnosis, and discuss treatment options.
 
|q3=List the differentials for your diagnosis, and discuss treatment options.
 
|a3=Hepatic lipidosis in cats may be a primary disease or may occur secondary to other metabolic, inflammatory or neoplastic conditions. Approximately 50% of cases are idiopathic. <br><br>
 
|a3=Hepatic lipidosis in cats may be a primary disease or may occur secondary to other metabolic, inflammatory or neoplastic conditions. Approximately 50% of cases are idiopathic. <br><br>
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Because these cats are already ill and stressed, extreme care must be taken not to cause further stress by force-feeding.<br><br>
 
Because these cats are already ill and stressed, extreme care must be taken not to cause further stress by force-feeding.<br><br>
 
Note: An additional photomicrograph is included here for comparison (29b) (Wright–Giemsa, ×100 oil). The multiple small, crisply defined cytoplasmic vacuoles within hepatocytes are characteristic of this condition.
 
Note: An additional photomicrograph is included here for comparison (29b) (Wright–Giemsa, ×100 oil). The multiple small, crisply defined cytoplasmic vacuoles within hepatocytes are characteristic of this condition.
|l3=Hepatic Lipidosis
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|l3=Hepatic Lipidosis#Treatment
 
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Latest revision as of 15:58, 23 September 2011


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Cytology 06a.jpg


A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (Wright–Giemsa, ×25).


Question Answer Article
Explain the abnormal RBC shape and the biochemistry abnormalities. Link to Article
Describe the cytological findings, and give your cytological interpretation. Link to Article
List the differentials for your diagnosis, and discuss treatment options. Link to Article



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