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Also known as: '''''Addison's disease
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| '''Addison's disease'''
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==Description==
 
==Description==
Addison's disease occurs due to a failure to produce adequate amounts of glucocorticoid and mineralocorticoid hormones from the adrenal cortex.  The majority of cases are '''primary''' and occur due to an autoimmune response directed at the endocrine cells of the adrenal glands, resulting in adrenocortical atrophy.  This is an example of a [[Type IV Hypersensitivity|type IV (delayed type) hypersensitivity response]]. Smaller numbers of primary cases are caused by haemorrhage, necrosis or neoplasia within the adrenal glands.  '''Secondary''' hypoadrenocorticism occurs due to a reduction in the secretion of ACTH from the anterior pituitary gland.  
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Addison's disease occurs due to a failure to produce adequate amounts of glucocorticoid and mineralocorticoid hormones from the adrenal cortex.  The majority of cases are '''primary''' and occur due to an autoimmune response directed at the endocrine cells of the adrenal glands, resulting in adrenocortical atrophy.  This is an example of a [[Type IV Hypersensitivity|type IV (delayed type) hypersensitivity response]]. Smaller numbers of primary cases are caused by haemorrhage, necrosis or neoplasia within the adrenal glands.  '''Secondary''' hypoadrenocorticism occurs due to a reduction in the secretion of ACTH from the anterior pituitary gland.  
    
===Primary Hypoadrenocorticism===
 
===Primary Hypoadrenocorticism===
[[Image:Adrenal atrophy.jpg|thumb|125px|Image of an adrenal gland undergoing atrophy.<br><small>Copyright A. Jefferies 2008</small>]]
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[[Image:Adrenal atrophy.jpg|thumb|125px|Image of an adrenal gland undergoing atrophy.<br><small>A. Jefferies 2008</small>]]
    
There are several possible causes of primary hypoadrenocorticism, including:  
 
There are several possible causes of primary hypoadrenocorticism, including:  
*'''Adrenal atrophy''' is thought to be an autoimmune disease caused by a type IV immune response.  Affected animals have an increased risk of developing other immune-mediated diseases, including [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]]. Grossly, the adrenal glands are small, difficult to locate and they are dark brown on cut sections. Histological analysis reveals the presence of an infiltrate of lymphocytes, plasma cells and macrophages.   
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*'''Adrenal atrophy''' is thought to be an autoimmune disease caused by a type IV immune response.  Affected animals have an increased risk of developing other immune-mediated diseases, including [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]]. Grossly, the adrenal glands are small, difficult to locate and they are dark brown on cut sections. Histological analysis reveals the presence of an infiltrate of lymphocytes, plasma cells and macrophages.   
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[[Image:Adrenal necrosis.jpg|thumb|125px|Histological section of an adrenal gland undergoing necrosis<br><small>Copyright A. Jefferies 2008</small>]]
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[[Image:Adrenal necrosis.jpg|thumb|125px|Histological section of an adrenal gland undergoing necrosis<br><small>A. Jefferies 2008</small>]]
[[Image:Adrenal necrosis2.jpg|thumb|125px|Image of an adrenal gland undergoing necrosis.  Note the areas of haemorrhage within the cortex of the gland.<br><small>Copyright A. Jefferies 2008</small>]]
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[[Image:Adrenal necrosis2.jpg|thumb|125px|Image of an adrenal gland undergoing necrosis.  Note the areas of haemorrhage within the cortex of the gland.<br><small>A. Jefferies 2008</small>]]
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*'''Adrenal necrosis''' may be caused by certain infections or it may be a sequel to other metabolic diseases. In horses, [[Salmonella|'''salmonellosis''']] may cause adrenal necrosis in horses but, in small animals, necrosis is more likely to occur due to myoarteritis in uraemic animals resulting in ischaemia of the adrenal gland. Idiopathic necrosis may occur with no apparent cause. Grossly, the glands contain areas of red haemorrhage with yellow necrotic foci.   
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*'''Adrenal necrosis''' may be caused by certain infections or it may be a sequel to other metabolic diseases. In horses, [[Salmonella|'''salmonellosis''']] may cause adrenal necrosis but, in small animals, necrosis is more likely to occur due to myoarteritis in uraemic animals resulting in ischaemia of the adrenal gland. Idiopathic necrosis may occur with no apparent cause. Grossly, the glands contain areas of red haemorrhage with yellow necrotic foci.   
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*'''Bilateral adrenalectomy''' or '''mitotane therapy''' may cause iatrogenic hypoadrenocorticism. Mitotane, which is used in the treatment of hyperadrenocorticism (Cushing's disease) selectively destroys the zona fasciculata and reticularis while sparing the essential zona glomerulosa.  Iatrogenic Addison's disease is a common sequel of its use.
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*'''Bilateral adrenalectomy''' or '''mitotane therapy''' may cause iatrogenic hypoadrenocorticism. Mitotane, which is used in the treatment of hyperadrenocorticism (Cushing's disease) selectively destroys the zona fasciculata and reticularis while sparing the essential zona glomerulosa.  Iatrogenic Addison's disease is a common sequel of its use.
    
===Secondary Hypoadrenocortisism===
 
===Secondary Hypoadrenocortisism===
Deficient pituitary secretion of ACTH.  Often '''iatrogenic''' due to withdrawal of glucocorticoid treatment. Prolonged high dose treatment induce adrenal atrophy due to the effect of negative feedback on the pituitary. The withdrawal of drug must be gradual to allow to adrenal gland to return to function over a period of time.   
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Deficient pituitary secretion of ACTH.  Often '''iatrogenic''' due to withdrawal of glucocorticoid treatment. Prolonged high dose treatment induce adrenal atrophy due to the effect of negative feedback on the pituitary. The withdrawal of drug must be gradual to allow to adrenal gland to return to function over a period of time.   
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Usually little effect on mineralocorticoids as ACTH has little trophic effect on their production.
 
Usually little effect on mineralocorticoids as ACTH has little trophic effect on their production.
    
===Pathophysiology===
 
===Pathophysiology===
The glucococorticoid hormone '''cortisol''' enables animals to cope with stress while the minerlaocorticoid '''aldosterone''' plays a critical role in the regulation of sodium and potassium concentrations and of extracellular fluid volume. Aldosterone normally acts to increase sodium reabsorption and potassium excretion in the kidney so deficient aldosterone secretion will result in '''hyponatraemia''', '''hypochloraemia''' and '''hyperkalaemia'''.  Since they are unable to regulate their body sodium concentration, Addisonian animals become severely dehydrated and hypovolaemic, reducing the perfusion of peripheral tissues. During an Addisonian crisis, this can result in gastro-intestinal haemorrhage and allow translocation of bacteria across the gut barrier.
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The glucococorticoid hormone '''cortisol''' enables animals to cope with stress while the minerlaocorticoid '''aldosterone''' plays a critical role in the regulation of sodium and potassium concentrations and of extracellular fluid volume. Aldosterone normally acts to increase sodium reabsorption and potassium excretion in the kidney so deficient aldosterone secretion will result in '''hyponatraemia''', '''hypochloraemia''' and '''hyperkalaemia'''.  Since they are unable to regulate their body sodium concentration, Addisonian animals become severely dehydrated and hypovolaemic, reducing the perfusion of peripheral tissues. During an Addisonian crisis, this can result in gastro-intestinal haemorrhage and allow translocation of bacteria across the gut barrier.
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Deficiency of cortisol results in '''hypoglycaemia''' (as cortisol usually antagonises the action of insulin), increased circulating levels of [[Lymphocytosis|lymphocytes]] and [[Eosinophilia|eosinophils]] and increased skin pigmentation. This latter syndrome occurs as low levels of glucocorticoids allow increased ACTH production as negative feedback on the pituitary is removed or decreased. As ACTH is released, so is MSH (Melanocyte Stimulating Hormone), increasing the pigmentation of the skin in chronic cases of hypoadrenocorticism.
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Deficiency of cortisol results in '''hypoglycaemia''' (as cortisol usually antagonises the action of insulin), increased circulating levels of [[Lymphocytosis|lymphocytes]] and [[Eosinophilia|eosinophils]] and increased skin pigmentation. This latter syndrome occurs as low levels of glucocorticoids allow increased ACTH production as negative feedback on the pituitary is removed or decreased. As ACTH is released, so is MSH (Melanocyte Stimulating Hormone), increasing the pigmentation of the skin in chronic cases of hypoadrenocorticism.
    
==Diagnosis==
 
==Diagnosis==
 
===Clinical Signs===
 
===Clinical Signs===
Addison's disease may present acutely as an '''Addisonian crisis''' or it may cause chronic disease over several months before it is diagnosed.  Acutely, affected animals present in '''hypovolaemic [[Shock|shock''']] with severe '''dehydration''' and '''bradycardia''' (caused by hyperkalaemia).  This feature of the crisis is extremely suggestive of Addison's disease as hypovolaemic animals would usually be expected to be tachycardic. As with any cause of hypovolaemia, the peripheral pulse is often weak, the capillary refill time is prolonged and the heart sounds may not be clearly audible on auscultation.
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Addison's disease may present acutely as an '''Addisonian crisis''' or it may cause chronic disease over several months before it is diagnosed.  Acutely, affected animals present in '''hypovolaemic [[Shock|shock''']] with severe '''dehydration''' and '''bradycardia''' (caused by hyperkalaemia).  This feature of the crisis is extremely suggestive of Addison's disease as hypovolaemic animals would usually be expected to be tachycardic. As with any cause of hypovolaemia, the peripheral pulse is often weak, the capillary refill time is prolonged and the heart sounds may not be clearly audible on auscultation.
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Addisonian animals may suffer [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|'''vomiting''']] as part of an acute crisis or as a chronic intermittent syndrome. In the chronic form of the disease, animals are frequently '''anorexic''' and '''weak'''.
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Addisonian animals may suffer [[Vomiting|'''vomiting''']] as part of an acute crisis or as a chronic intermittent syndrome. In the chronic form of the disease, animals are frequently '''anorexic''' and '''weak'''.
    
===Laboratory Tests===
 
===Laboratory Tests===
 
Complete analysis of blood samples is indicated for animals presenting acutely and for those that have a history of chronic intermittent vomiting and anorexia.  The following changes may be documented:
 
Complete analysis of blood samples is indicated for animals presenting acutely and for those that have a history of chronic intermittent vomiting and anorexia.  The following changes may be documented:
 
*'''Haemoconcentration''' in an acute crisis due to rapid dehydration.
 
*'''Haemoconcentration''' in an acute crisis due to rapid dehydration.
*'''Non-regenerative anaemia''' in chronic form as glucocorticoid deficiency decreases erythropoeisis. Since it is possible for animals to undergo an acute crisis after suffering from hypoadrenocorticism for several weeks, any anaemia may be masked by the haemoconcentration that occurs due to hypovolaemia.
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*'''Non-regenerative anaemia''' in chronic form as glucocorticoid deficiency decreases erythropoeisis. Since it is possible for animals to undergo an acute crisis after suffering from hypoadrenocorticism for several weeks, any anaemia may be masked by the haemoconcentration that occurs due to hypovolaemia.
 
*'''Electrolyte imbalances''' occur in 90% of patients, typically '''hyperkalaemia''', '''hyponatraemia''' and '''hypochloraemia'''.  The sodium: potassium ratio of a normal animal is >27: 1 but this falls to <25: 1 in Addisonian animals.
 
*'''Electrolyte imbalances''' occur in 90% of patients, typically '''hyperkalaemia''', '''hyponatraemia''' and '''hypochloraemia'''.  The sodium: potassium ratio of a normal animal is >27: 1 but this falls to <25: 1 in Addisonian animals.
 
*'''Pre-renal [[Azotaemia|azotaemia]]''' is common as hypovolaemic animals are unable to maintain adequate renal perfusion.   
 
*'''Pre-renal [[Azotaemia|azotaemia]]''' is common as hypovolaemic animals are unable to maintain adequate renal perfusion.   
 
*'''Hypoglycaemia''' is a common finding in animals presenting in Addisonian crisis.
 
*'''Hypoglycaemia''' is a common finding in animals presenting in Addisonian crisis.
*'''[[Eosinophilia]]''' and '''[[Lymphocytosis|lymphocytosis]]''' occur due to the deficiency in glucocorticoids. In such a severely ill animal, a stress leucogram would usually be expected so this pattern is highly suggestive of hypoadrenocorticism. An elevated blood [[Urea|urea]] concentration may also occur due to gastro-intestinal haemorrhage which is a common finding in animals with Addison's disease.
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*'''[[Eosinophilia]]''' and '''[[Lymphocytosis|lymphocytosis]]''' occur due to the deficiency in glucocorticoids. In such a severely ill animal, a stress leucogram would usually be expected so this pattern is highly suggestive of hypoadrenocorticism. An elevated blood [[Urea|urea]] concentration may also occur due to gastro-intestinal haemorrhage which is a common finding in animals with Addison's disease.
    
===Other Tests===
 
===Other Tests===
Additional tests are available to confirm the diagnosis and assess the need for further supportive treatment.  An '''ACTH stimulation test''' should be performed as soon as possible in animals presenting acutely. The pre-stimulation sample can be taken immediately, the ACTH (tetracosactin) is administered and the post- sample is collected after 1.5-2 hours.  Although the results of the test may not be available for 24-48 hours, it is very useful to confirm the diagnosis when acute renal failure is considered to be a major differential diagnosis.  A positive result is recorded if the level of cortisol is initially low and if this fails to respond to the injection of ACTH.
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Additional tests are available to confirm the diagnosis and assess the need for further supportive treatment.  An '''ACTH stimulation test''' should be performed as soon as possible in animals presenting acutely. The pre-stimulation sample can be taken immediately, the ACTH (tetracosactin) is administered and the post- sample is collected after 1.5-2 hours.  Although the results of the test may not be available for 24-48 hours, it is very useful to confirm the diagnosis when acute renal failure is considered to be a major differential diagnosis.  A positive result is recorded if the level of cortisol is initially low and if this fails to respond to the injection of ACTH.
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Since hyperkalaemia has significant effects on the membrane potential of excitable tissues, it is useful to perform an electrocardiogram ('''ECG''') to assess the function of the heart. Findings consistent with hyperkalaemia include small or absent P waves (indicating sino-atrial standstill), wide and small QRS complexes, short Q-T intervals, peaked T waves and long P-R intervals.
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Since hyperkalaemia has significant effects on the membrane potential of excitable tissues, it is useful to perform an electrocardiogram ('''ECG''') to assess the function of the heart. Findings consistent with hyperkalaemia include small or absent P waves (indicating sino-atrial standstill), wide and small QRS complexes, short Q-T intervals, peaked T waves and long P-R intervals.
    
===Diagnostic Imaging===
 
===Diagnostic Imaging===
'''Plain radiographs''' of the chest and abdomen may show signs of hypovolaemia, including '''microcardia''', '''pulmonary underperfusion''' and '''microhepatica'''.  Animals with Addison's disease may also develop [[Megaoesophagus|megaoesophagus]] due to muscle weakness. Ultrasound scans of the adrenal glands may be indicated to detect any evident pathological process that may account for the hypoadrenocorticism.
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'''Plain radiographs''' of the chest and abdomen may show signs of hypovolaemia, including '''microcardia''', '''pulmonary underperfusion''' and '''microhepatica'''.  Animals with Addison's disease may also develop [[Megaoesophagus|megaoesophagus]] due to muscle weakness. Ultrasound scans of the adrenal glands may be indicated to detect any evident pathological process that may account for the hypoadrenocorticism.
    
==Treatment==
 
==Treatment==
 
===Stabilisation===
 
===Stabilisation===
Since collpased, bradycardic animals are unlikely to survive for long, urgent intervention is required to stabilise these patients. '''Intra-venous 0.9% sodium chloride (saline) solution''' should be provided at shock rates to restore normovolaemia and begin to correct the electrolyte imbalances.  Additional '''glucose''' can be added to fluids in hypoglycaemic animals but blood glucose levels should be monitored closely if this is undertaken.   
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Since collapsed, bradycardic animals are unlikely to survive for long, urgent intervention is required to stabilise these patients. '''Intra-venous 0.9% sodium chloride (saline) solution''' should be provided at shock rates to restore normovolaemia and begin to correct the electrolyte imbalances.  Additional '''glucose''' can be added to fluids in hypoglycaemic animals but blood glucose levels should be monitored closely if this is undertaken.   
    
When the diagnosis has been made with some certainty, '''intra-venous glucocorticoid replacement therapy''' can be initiated together with a '''mineralocorticoid'''.  Dexamethasone is the corticosteroid of choice as it has greater mineralocorticoid activity than other products.  Although there is an intra-muscular injectable mineralocorticoid (desoxycorticosterone acetate) available in the USA, this is not usually required for stabilisation.
 
When the diagnosis has been made with some certainty, '''intra-venous glucocorticoid replacement therapy''' can be initiated together with a '''mineralocorticoid'''.  Dexamethasone is the corticosteroid of choice as it has greater mineralocorticoid activity than other products.  Although there is an intra-muscular injectable mineralocorticoid (desoxycorticosterone acetate) available in the USA, this is not usually required for stabilisation.
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===Management===
 
===Management===
In the long term, animals with Addison's disease require only a mineralocorticoid on a daily basis with intermittent courses of glucocorticoids during times of stress. The mineralocorticoid '''fludrocortisone acetate''' is available in an oral preparation and this is used most commonly for management.
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In the long term, animals with Addison's disease require only a mineralocorticoid on a daily basis with intermittent courses of glucocorticoids during times of stress. The mineralocorticoid '''fludrocortisone acetate''' is available in an oral preparation and this is used most commonly for management.
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During times of '''stress''', courses of corticosteroids (e.g. prednisolone) should be provided and '''table salt''' should be added to the diet.  Water should be avaiable at all time and blood electrolyte levels should be monitored at regular intervals to ensure that the correct dose of fludrocortisone is used.
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During times of '''stress''', courses of corticosteroids (e.g. prednisolone) should be provided and '''table salt''' should be added to the diet.  Water should be available at all time and blood electrolyte levels should be monitored at regular intervals to ensure that the correct dose of fludrocortisone is used.
    
==Prognosis==
 
==Prognosis==
 
The prognosis for long term survival is excellent for animals with hypoadrenocorticism provided that any crisis is controlled.  
 
The prognosis for long term survival is excellent for animals with hypoadrenocorticism provided that any crisis is controlled.  
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==Literature Search==
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[[File:CABI logo.jpg|left|90px]]
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Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
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<br><br><br>
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[http://www.cabdirect.org/search.html?it=any&q2=Addison%27s+disease&q1=Hypoadrenocorticism&calendarInput=yyyy-mm-dd&q3=Addisons+disease&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=OR&options3=OR&occuring3=title&occuring2=title&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=12&x=43 Hypoadrenocorticism publications]
    
==References==
 
==References==
 
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
 
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
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[[Category:Cell Mediated Autoimmune Diseases]][[Category:To Do - James]][[Category:Dog]][[Category:To Do - Review]]
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[[Category:Cell Mediated Autoimmune Diseases]][[Category:Dog]][[Category:Expert Review]]
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