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* Leptin is a hormonal peptide produced by adipocytes (fat cells).
 
* Leptin is a hormonal peptide produced by adipocytes (fat cells).
 
* The amount of leptin in the blood is directly related to the amount of fat in the body.
 
* The amount of leptin in the blood is directly related to the amount of fat in the body.
* Leptin receptors are found in the [[Liver_-_Anatomy_%26_Physiology|liver]], [[Urinary_System_-_Anatomy_%26_Physiology#The_Kidney|kidney]], [[Heart_-_Anatomy_%26_Physiology|heart]], skeletal muscles, pancreas, anterior pituitary gland and hypothalamus.
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* Leptin receptors are found in the [[Liver_-_Anatomy_%26_Physiology|liver]], [[Urinary_System_-_Anatomy_%26_Physiology#The_Kidney|kidney]], [[Heart_-_Anatomy_%26_Physiology|heart]], [[Muscles_-_Anatomy_%26_Physiology#Skeletal_Muscle|skeletal muscles]], pancreas, anterior pituitary gland and hypothalamus.
 
* Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons.
 
* Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons.
  
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