Flaviviridae

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VIRUSES




Introduction

This group of viruses has three distinct genera, two of which are of veterinary concern. Flaviviruses, which are endemic vector-borne neurotropic viruses, include louping ill and West Nile Virus. Pestiviruses include Swine Fever and Bovine Virus Diarrhoea and present more hemorrhagic disease. Hepatitis C in man is also grouped in this classification.

Morphology

  • Medium sized enveloped viruses

Types and Subtypes

Flaviviruses

Louping Ill

West Nile Virus

Yellow Fever (man)

Pestiviruses

Classical Swine Fever

Border Disease Virus

Bovine Virus Diarrhoea Virus

Pestiviruses

Bovine Viral Diarrhoea & Mucosal Disease Virus may also contribute to Enzootic pneumonia of calves, may cause growth retardation lattice


Swine Fever Virus


  • Border Disease
    • In sheep
    • Virus crosses placenta
    • Tropism for foetal lymphoid, hair follicle and CNS tissue
    • Lambs born weak, small
    • Hairy shaker syndrome
    • Hair rather than wool coats and cerebellar hypoplasia