Difference between revisions of "Actinobacillus pleuropneumoniae"
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− | *Contagious | + | *[[Contagious Porcine Pleuropneumonia]] especially of pigs under 6 months |
*Endemic in UK | *Endemic in UK | ||
*12 serotypes causing the same disease | *12 serotypes causing the same disease | ||
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***Different ''Actinobacillus pleuropneumonia'' serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III | ***Different ''Actinobacillus pleuropneumonia'' serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III | ||
***Toxins introduce pores into cell membranes | ***Toxins introduce pores into cell membranes | ||
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[[Category:Actinobacillus_species]][[Category:Pig]] | [[Category:Actinobacillus_species]][[Category:Pig]] | ||
+ | [[Category:To_Do_-_Bacteria]] |
Revision as of 09:51, 25 June 2010
- Contagious Porcine Pleuropneumonia especially of pigs under 6 months
- Endemic in UK
- 12 serotypes causing the same disease
- Different serotypes in different regions, with serotypes 3,6 and 8 the most common in the UK
- Pathogenesis and pathogenicity:
- Virulent strains possess capsules which are antiphagocytic and immunogenic
- Fimbriae allow the bacteria to attach to cells of the respiratory tract
- Damaged neutrophils in the lungs produce lytic enzymes
- The sustained inflammatory response causes tissue necrosis
- Lungs consolidated and necrotic with fibrinous pleuisy at post mortem
- Produce three cytotoxins which belong to the repeats-in-structural-toxin (RTX) cytolysin family
- RTX toxins:
- Several peptide repeats within the molecules
- Produced by various Gram-negative bacteria
- Possess four contiguous genes, A, B, C and D
- A is the structural gene; B and D are required for secretion; C allows post-translational activation of the gene product of A into a functional product
- ApxI is a strong haemolysin with cytolytic activity
- ApxII is a weak haemolysin
- ApxIII is a cytotoxin
- Different Actinobacillus pleuropneumonia serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III
- Toxins introduce pores into cell membranes