Difference between revisions of "Bovine Spongiform Encephalopathy"
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Also known as: '''''BSE — Bovine Spongiform Encephalopathy''''', '''''TSE — Transmissible Spongiform Encephalopathy'''''', '''''Mad Cow Disease''''', '''''Prion — proteinaceous infectious particle''''', '''''Scrapie — a transmissble prion affecting sheep that causes non-febrile neurological disease''''' | Also known as: '''''BSE — Bovine Spongiform Encephalopathy''''', '''''TSE — Transmissible Spongiform Encephalopathy'''''', '''''Mad Cow Disease''''', '''''Prion — proteinaceous infectious particle''''', '''''Scrapie — a transmissble prion affecting sheep that causes non-febrile neurological disease''''' | ||
==Introduction== | ==Introduction== | ||
| − | + | Transmissible Spongiform Encephalopathies (TSEs) are neurological diseases that have been found in humans, cattle, sheep and other mammals (e.g. cats, goats, deer, antelope). The agent of disease is believed to be an abnormal prion protein (or is prion associated). An abnormal prion is a protein with an abnormal folding structure when compared to the naturally occurring prion found in nervous and lymphoreticular tissues. Various abbreviations are in use to refer to this: Prion Protein (PrP); Abnormal Prion Protein (PrP<sup>ab</sup>); Resistant Prion Protein (PrP<sup>res</sup>); Scrapie Prion Protein PrP<sup>sc</sup>) and others. | |
==Signalment== | ==Signalment== | ||
==Clinical Signs== | ==Clinical Signs== | ||
| + | Clinical signs include progressive ataxia and pruritus. | ||
| + | |||
==Diagnosis== | ==Diagnosis== | ||
| + | In most instances the abnormal prion is resistant to protein kinase digestion, a feature used in diagnostic techniques. Histology (immunohistochemistry) usually shows vacuolation and an accumulation of prion proteins in various parts of the CNS (especially the brain and spinal cord). | ||
| + | |||
==Treatment== | ==Treatment== | ||
==Control== | ==Control== | ||
==Refereneces== | ==Refereneces== | ||
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[[Category:Transmissible_Spongiform_Encephalopathies]] | [[Category:Transmissible_Spongiform_Encephalopathies]] | ||
[[Category:To_Do_-_Jaimie Meagor]] | [[Category:To_Do_-_Jaimie Meagor]] | ||
Revision as of 13:23, 6 June 2011
Also known as: BSE — Bovine Spongiform Encephalopathy, TSE — Transmissible Spongiform Encephalopathy', Mad Cow Disease, Prion — proteinaceous infectious particle, Scrapie — a transmissble prion affecting sheep that causes non-febrile neurological disease
Introduction
Transmissible Spongiform Encephalopathies (TSEs) are neurological diseases that have been found in humans, cattle, sheep and other mammals (e.g. cats, goats, deer, antelope). The agent of disease is believed to be an abnormal prion protein (or is prion associated). An abnormal prion is a protein with an abnormal folding structure when compared to the naturally occurring prion found in nervous and lymphoreticular tissues. Various abbreviations are in use to refer to this: Prion Protein (PrP); Abnormal Prion Protein (PrPab); Resistant Prion Protein (PrPres); Scrapie Prion Protein PrPsc) and others.
Signalment
Clinical Signs
Clinical signs include progressive ataxia and pruritus.
Diagnosis
In most instances the abnormal prion is resistant to protein kinase digestion, a feature used in diagnostic techniques. Histology (immunohistochemistry) usually shows vacuolation and an accumulation of prion proteins in various parts of the CNS (especially the brain and spinal cord).