Difference between revisions of "Trypanosomosis"

From WikiVet English
Jump to navigation Jump to search
Line 74: Line 74:
 
==References==
 
==References==
 
<references/>
 
<references/>
Animal Health & Production Compendium, datasheet, accessed 02/06/2011 @ http://www.cabi.org/ahpc/
+
Merck Veterinary Manual, '''Tetse-transmitted Trypanosomiasis''' accessed online 03/06/2011 @ http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/10413.htm
  
[[Category: To Do – CABI Review]]
+
[[Category: To Do – Steph]]

Revision as of 18:11, 3 June 2011

Also Known As — NaganaTypanosomiasis

Introduction

Schematic diagram of Trypanosoma brucei

Trypanosomosis is a disease caused by protozoan pathogens of the genus Trypanosoma.

Trypanosomosis causes a wasting disease in cattle and sleeping sickness in humans.

T. cruzi is the most important species in veterinary medicine.

Causative Organisms

T. cruzi occurs in South America where it is transmitted by a triatomid bug and infects armadillos, possums and humans. It is known as Chagas’ Disease.

T. brucei and T. Equiperdum affect horses, the latter causing venereal dourine.

T. simiae causes fatal pyrexia in pigs while T. Congolense is milder in the same species.

T. brucei and T. Congolense can also affect dogs and cats causing acute fever, anaemia and neurological signs.

T. brucei causes skin infections in donkeys.

T. melophagum and T. Theileri are non-pathogenic species present in the UK.

Transmission

Trypanosomiasis is spread by Tsetse flies.

Clinical Signs

Clinical disease varies widely with death occurring from 1 week to months after infection. T. vivax is known for is rapid mortality while T. brucei and T. congolense hosts often survive for prolonger periods. Infection of large numbers of insect vectors is common in these circumstances

Ruminants

Enlarged lymph nodes and spleen. Later in the disease course the lymph nodes and spleen shrink due to lymphoid exhaustion.

Haemolytic anaemia is a cardinal feature.

Chronic infection causes heart failure and associated signs and death.

Plasma cell hypertrophy and hypergammaglobulinaemia are evident on haematology and biochemistry.

Emaciation

Abortion and infertility

Horses

Oedema of the limbs and genitalia. Dourine – genital and abdominal oedema and neurological signs.

Donkeys

Skin infections

Dogs and Cats

Pyrexia, myocarditis, myositis, corneal opacity and neurological signs.

Diagnosis

Trypanosomes in blood

Microscopic identification on trypanosome parasites in the host blood on a smear with Giemsa staining.

Motile trypanosomes may be demonstrable in a haematocrit tube at the plasma: buffy coat interface.

Treatment

A variety of drugs can be used to treat trypanosomiasis including diminazene, homidium, isometadium, suramin and melarsomine.

Control

Separation of livestock and wild animals is effective but difficult.

Use of trypanotolerant livestock breeds. Tsetse fly control by sprays, traps etc

Prophylactic drug therapy with quinapyramine or homidium is effective.


References

Merck Veterinary Manual, Tetse-transmitted Trypanosomiasis accessed online 03/06/2011 @ http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/10413.htm