View source for Equine Internal Medicine Q&A 05

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'''Shown is an eight-year-old pony gelding with weight loss (approximately 45kg), inappetence and non-painful pitting oedema of the ventral abdomen. The heart sounds normal, the heart rate is 40bpm and the jugular veins are not distended. The pony is azotaemic (creatinine 194.5␣mol/l; 2.2mg/dl) and the urinalysis reveals specific gravity of 1.014 and proteinuria (urine protein:creatinine ratio 3:1). The PCV of the pony is 35% and the plasma protein is 45g/l.'''

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<FlashCard questions="2">
|q1=What is the most likely diagnosis in this pony?
|a1= 
The most likely diagnosis is glomerulonephritis with renal failure.
|l1=Glomerulonephritis
|q2=What is the presumed pathological mechanism of the disease?
|a2=The presumed pathological mechanism of glomerulonephritis is persistent immune complex deposition or in situ formation in the glomerulus.<br><br>
In the horse the deposits are most severe within the glomerular capillary walls. <br>
These deposits cause activation of soluble and cellular mediators within the kidney, causing protein loss in the urine, decreased glomerular filtration and renal failure.
|l2=Glomerulonephritis
</FlashCard>

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