View source for Injection Site Reaction

*May be caused by subcutaneous injections
*Granulomatous nodules form with central necrotic and foreign material
*Macrophages and multinucleated giant cells around the centre
*Surrounded by granulation tissue, perivascular lymphocytes that may form lymphoid follicles, eosinophils
*Cats may develop [[Vaccine-Associated Sarcoma|fibrosarcomas secondary to vaccination]]
*Dogs, especially poodles, may develop lymphoplasmacytic panniculitis and perivasculitis, vasculitis and follicular atrophy secondary to killed rabies vaccine


[[Category:Integumentary System - Physical Damage]]