Changes

==Urinary System==

==Urinary System==

===Amyloidosis===

===Amyloidosis===

Amyloidosis causes soluable proteins to polymerise into insoluable fibrils resulting in chronic infections and impaired renal function. This condition frequently in older (>1) female hamsters.

Amyloidosis causes soluable proteins to polymerise into insoluable fibrils resulting in chronic infections and impaired renal function. This condition frequently in older (>1) female hamsters.

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===Arteriolar Nephrosclerosis (Hamster Nephrosis)===

===Arteriolar Nephrosclerosis (Hamster Nephrosis)===

Arteriolar nephrosclerosis is a degenerative disease occurring most commonly in older hamsters, particularly females. Clinical symptoms will include weight loss and polyuria/polydipsia. Some links have been made between this disease and 'Lymphocytic choriomeningitis' virus infections (see below) which results in renal vascular hypertension. Arteriolar nephrosclerosis may also be concurrent with amyloidosis (above).  

Arteriolar nephrosclerosis is a degenerative disease occurring most commonly in older hamsters, particularly females. Clinical symptoms will include weight loss and polyuria/polydipsia. Some links have been made between this disease and 'Lymphocytic choriomeningitis' virus infections (see below) which results in renal vascular hypertension. Arteriolar nephrosclerosis may also be concurrent with amyloidosis (above).  

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===Diabetes Mellitus===

===Diabetes Mellitus===

Known to occur spontaneously in some inbred strains of Chinese hamster, inherited via a recessive gene. Clinical symptoms include weight loss, glucose intolerance, mild to severe hyperglycemia, polydipsia, polyuria, hypoinsulinemia and ketouria.

Known to occur spontaneously in some inbred strains of Chinese hamster, inherited via a recessive gene. Clinical symptoms include weight loss, glucose intolerance, mild to severe hyperglycemia, polydipsia, polyuria, hypoinsulinemia and ketouria.

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Microscopic pathology will include pancreatic islet involution with severe and widespread nuclear pyknotic (irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis), shrunken and eosinophilic cytoplasm with cytoplasmic vacuoles and loss of granules.

Microscopic pathology will include pancreatic islet involution with severe and widespread nuclear pyknotic (irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis), shrunken and eosinophilic cytoplasm with cytoplasmic vacuoles and loss of granules.

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==Respiratory System==

==Respiratory System==

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