Difference between revisions of "Stress Leucogram"
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A stress leuocogram is a finding on a haematological test. It is characterised by a [[Neutrophilia|neutrophilia]], [[Monocytosis|monocytosis]], [[Lymphopaenia|lymphopaenia]] and [[Eosinopaenia|eosinopaenia]] | A stress leuocogram is a finding on a haematological test. It is characterised by a [[Neutrophilia|neutrophilia]], [[Monocytosis|monocytosis]], [[Lymphopaenia|lymphopaenia]] and [[Eosinopaenia|eosinopaenia]] | ||
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==What can this indicate== | ==What can this indicate== | ||
| − | A stress leucogram can be completely normal as part of the stress response. It is caused by endogenous release of | + | A stress leucogram can be completely normal as part of the stress response. It is caused by endogenous release of adrenaline/epinephrine which causes the above haematological parameters to change, this release can be triggered by pain, stress or excitement. See below for the mechanism for this change. |
| − | A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of | + | A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of adrenaline released endogenously, or via iatrogenic injection of exogenous corticosteroids. |
==How does it occur?== | ==How does it occur?== | ||
| − | The | + | The corticosteroid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination |
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Revision as of 14:05, 11 February 2011
A stress leuocogram is a finding on a haematological test. It is characterised by a neutrophilia, monocytosis, lymphopaenia and eosinopaenia
A useful pneumonic to remember is SMILED, which stands for Segmented (neutrophils) and Monocytes Increased, Lymphocytes and Eosinophils Decreased.
What can this indicate
A stress leucogram can be completely normal as part of the stress response. It is caused by endogenous release of adrenaline/epinephrine which causes the above haematological parameters to change, this release can be triggered by pain, stress or excitement. See below for the mechanism for this change.
A stress leucogram can also be seen in Cushing's Disease (AKA hyperadrenocorticism) where there is a pathological increase in the amount of adrenaline released endogenously, or via iatrogenic injection of exogenous corticosteroids.
How does it occur?
The corticosteroid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination