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[[Equine Hyperlipidaemia]]
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[[Ovine White Liver Disease]]
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===associated with derangement of carbohydrate metabolism===
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====[[DM|Diabetes mellitus]]====
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*where there is insufficient insulin or a decrease in number of insulin receptors in cells
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*seen mostly in dogs
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*produces a markedly fatty [[Liver - Anatomy & Physiology|liver]] due to release of fat from the fat stores for use as an energy source
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====Ketosis====
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*due to an excessive drain on carbohydrate stores because pregnant and lactating animals have a continuous demand for glucose
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*ketosis results when fat metabolism which occurs in response to the increased energy demand is excessive
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*ketone bodies accumulate in the blood and there is marked fatty change in the [[Liver - Anatomy & Physiology|liver]]
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*can occur in starvation but commonly seen in two conditions in livestock:
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=====ketosis of cattle (acetonemia)=====
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*occurs in high yielding dairy cows a few weeks postpartum
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*due to excessive loss of glucose in the milk
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*milk yield drops
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*smell of ketones on the breath
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*ketones excreted in the milk
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*self-limiting condition
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=====pregnancy toxaemia in sheep=====
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*occurs in ewes in late pregnancy carrying twin lambs ''''twin lamb disease''''
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*drain of carbohydrate stores is due to rapidly growing foetuses
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*serious condition and highly fatal
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*clinical signs (neurological)
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**apparent blindness
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**dullness
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**convulsions
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**coma
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*sequelae
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**foetuses die
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**apparent recovery in ewe until toxaemia from the decomposing foetuses results in the ewe's death
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===associated with anoxia and toxaemia===
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====anoxia====
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*passive congestion
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*anaemias
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====toxaemia====
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*toxins absorbed from the gut interfere with many stages of triglyceride metabolism
      
[[Category:Liver_-_Pathology]]
 
[[Category:Liver_-_Pathology]]
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