Changes

* Lipophage

* Lipophage

* [[Bones - Anatomy & Physiology#Osteoclasts|Osteoclasts]] in bone

* [[Bones - Anatomy & Physiology#Osteoclasts|Osteoclasts]] in bone

* [[#Microglial Cells|Microglial cell]] in bone & brain

* [[Neurons_- Anatomy & Physiology#Microglial_Cells|Microglial cell]] in bone & brain

* Specialised histiocytes

* Specialised histiocytes

** Epithelioid cell

** Epithelioid cell

* Histiocytic giant cell

* Histiocytic giant cell

** Langhan’s cell

** Langerhans cell

** Touton giant cell</p>

** Touton</p>

[[Image:Monocyte Picture.jpg|thumb|right|150px|Monocyte Picture - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

[[Image:Monocyte Picture.jpg|thumb|right|150px|Monocyte Picture - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

<p>Monocytes can live for months to years in the circulation.</p>

<p>Monocytes can live for months to years in the circulation.</p>

<p>Monocytes are referred to as macrophages once they enter a tissue by '''diapedesis'''.</p>

<p>Monocytes are referred to as macrophages once they enter a tissue by '''diapedesis'''.</p>

<p>Monocytes/macrophages act as phagocytes, removing particular antigens. They also act as antigen presenting cells to take up, process and present antigen to [[Lymphocytes#T cells|T cells]].</p>

<p>Monocytes/macrophages act as phagocytes, removing particular antigens. They also act as antigen presenting cells to take up, process and present antigen to [[T cells]].</p>

===In pathology===

==Monocytosis==

*[[Monocytosis|Monocytosis]]

An increase in the number of monocytes (haematogenous macrophages) in the blood is known as a [[Monocytosis|monocytosis]]. It occurs in conjunction with other changes inidicative of a [[Stress Leucogram|stress leucogram]] or it may occur independently. Monocytes in the blood represent a brief transitional stage as they quickly move into tissues and differentiate further to tissue macrophages; they rarely perform any notable functions whilst in the bloodstream but they have been found to phagocytose red blood cells in cases of immune-mediated haemolytic anaemia. The major causes of monocytosis are:

*Stress leucogram mediated by the production or administration of glucocorticoids (plus a neutrophilia, eosinopenia and lymphopenia).

*Chronic inflammatory processes, including chronic bacterial infections and chronic inflammatory diseases of the liver (chronic hepatitis and cholangitis) and pancreas (chronic pancreatitis).

<center><b><sup>Blood cells: [[Erythrocytes|Erythrocytes]] |

*Granulomatous disease results in monocytosis as monocytes are recruited to contain certain types of bacteria (namely Mycobacteria spp., Nocardia spp., Actinomyces and Rhodococcus equi) or foreign bodies.

[[Basophils|Basophils]], [[Eosinophils|Eosinophils]], [[Lymphocytes - Introduction|Lymphocytes]], [[Macrophages|Macrophages]], [[Mast Cells|Mast cells]], [[Monocytes|Monocytes]] & [[Neutrophils|Neutrophils]] |  [[Thrombocytes|Thrombocytes]] & [[Thrombopoiesis#Megakaryocyte|Megakaryocytes]]</sup></b></center>

[[Category:Blood_Cells]]

[[Category:Blood_Cells]] [[Category:Kate English reviewing]]