Difference between revisions of "Inclusion Body Rhinitis"

Revision as of 16:31, 17 February 2011

Inclusion body rhinitis (Image sourced from Bristol Biomed Image Archive with permission)

Herpesviridae, porcine cytomegalovirus
Disease of suckling piglets 1-5 wks of age
Clinical signs: those associated with acute/subacute rhinitis (ie: serous nasal discharge, progressing to catarrhal or purulent discharge with time and secondary bacterial infections; sneezing; pyrexia), fever in young piglets (3-8wks old)
May progress to sinusitis, otitis media or pneumonia
Morbitity high, mortality low
Gross pathology - catarrhal discharge becoming purulent (secondary infection)
Histology:
- Large basophilic intranuclear inclusion bodies in the surface and subepithelium of nasal and sinus glandular epithelium with lymphocytic infiltration of the mucosa
- Bursting of nucleus with cell necrosis and sloughing of necrotic epithelium
Can develop viraemic stage, with inclusions and focal necrotising lesions in other organs eg: renal tubular epithelium
- Usually younger piglets, can die during this phase
Usually resolves if uncomplicated but rhinitis may persist if secondary infection is present
May persist in pulmonary macrophages

@@ Line 5: / Line 5: @@
 *Disease of suckling piglets 1-5 wks of age
 *Clinical signs: those associated with acute/subacute [[Rhinitis#Infectious causes of rhinitis|rhinitis]] (ie: serous nasal discharge, progressing to catarrhal or purulent discharge with time and secondary bacterial infections; sneezing; pyrexia), fever in young piglets (3-8wks old)
-*May progress to [[Paranasal Sinuses Inflammatory - Pathology#Sinusitis|sinusitis]], otitis media or [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]]
+*May progress to [[Sinusitis|sinusitis]], otitis media or [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]]
 *Morbitity high, mortality low
 *Gross pathology - catarrhal discharge becoming purulent (secondary infection)