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Systemic Lupus Erythematosus (view source)
Revision as of 16:54, 22 February 2011
, 16:54, 22 February 2011no edit summary
* Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''
* Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''
==From Pathology==
*'''Systemic (SLE)'''
**Multiple organs involved
**Cats, dogs, horses
**Immune dysregulation:
***Damaged T-cell suppressor function, either primary deficiency or antibody mediated
***Cytokine dysregulation
***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
**Lesions localised or generalised
**Erythema, alopecia, depigmentation, crusting and scaling, ulceration
**Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
*'''Discoid'''
**Milder variant of systemic
**Depigmentation, erythema, scaling, erosions, ulceration, crusting
**Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
**Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment
[[Category:Integumentary System - Autoimmune Reactions]]
[[Category:Antibody Mediated Autoimmune Diseases]]
[[Category:Antibody Mediated Autoimmune Diseases]]
[[Category:Immunological Diseases - Cat]][[Category:Immunological Diseases - Dog]]
[[Category:Immunological Diseases - Cat]][[Category:Immunological Diseases - Dog]]