Changes

==Histopathology==

==Histopathology==

[[Image:Case pic 3.jpg|right|thumb|125px|<small><center>'''Histology; hypertrophic cardiomyopathy'''. Courtesy of K. Hughes</center></small>]]

[[Image:Case pic 3.jpg|right|thumb|125px|<small><center>'''Histology'''. Courtesy of K. Hughes</center></small>]]

Samples were taken for histological examination (Stained with H and E):

Samples were taken for histological examination (Stained with H and E):

*The cardiac myocytes are multifocally widely spaced and infiltrated by streams of spindle shaped cells (fibroblasts).  

*The cardiac myocytes are multifocally widely spaced and infiltrated by streams of spindle shaped cells (fibroblasts).  

[[Image:Case pic 4.jpg|left|thumb|125px|<small><center>'''Histology; Massons Trichrome'''. Courtesy of K. Hughes</center></small>]]

[[Image:Case pic 4.jpg|right|thumb|125px|<small><center>'''Massons Trichrome'''. Courtesy of K. Hughes</center></small>]]

Some sections were stained with Massons Trichrome:

Some sections were stained with Massons Trichrome:

The fibrosis seen is a common sequale to this type of disease.  The hypertrophy in the ventricular wall limits blood supply to the inner third of myocardium.  Reduced perfusion stimulates replacement of degenerate myocytes with fibrous tissue, extending into the endocardium.

The fibrosis seen is a common sequale to this type of disease.  The hypertrophy in the ventricular wall limits blood supply to the inner third of myocardium.  Reduced perfusion stimulates replacement of degenerate myocytes with fibrous tissue, extending into the endocardium.