Difference between revisions of "Joint Response to Injury"
Jump to navigation
Jump to search
| Line 1: | Line 1: | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
===Causes of injury === | ===Causes of injury === | ||
| Line 34: | Line 22: | ||
***+/- synovitis | ***+/- synovitis | ||
**Hyperplasia | **Hyperplasia | ||
| + | |||
| + | |||
| + | [[Category:Joints - Pathology|A]] | ||
Revision as of 16:42, 3 March 2011
Causes of injury
- Trauma
- Instability
- Lubrication failure
- Infectious organisms
- Immune-mediated disease
Reaction to injury
- Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
- Chondrocyte hyperplasia is ineffective at filling the defect
- Non-painful
- Defects reaching subchondral bone
- Filled with vascular fibroous tissue undergoing metaplasia into cartilage
- Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
- Superficial defects are long standing
- Synovial membranes respond by:
- Villous hypertrophy
- +/- synovitis
- Hyperplasia
- Villous hypertrophy